Longitudinal developmental analysis of prethalamic eminence derivatives in the chick by mapping of Tbr1 in situ expression

Alonso, Antonia; Trujillo, Carmen María; Puelles, Luis

doi:10.1007/s00429-019-02015-3

Cited by 18 publications

(39 citation statements)

References 92 publications

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“…In contrast, Dlx family genes are strongly expressed in the alar hypothalamus only at the subparaventricular area, which occupies the ventral part of the alar hypothalamus (Figure 1b (Figure 1c), though the PThE still extends into its evaginated flap incorporated into part of the caudomedial hemispheric wall. We believe that the true rostral border of the deformed PThE probably relates to the amygdala and ventrocaudal hippocampus, as can be observed at early developmental stages (Alonso et al, 2020;fig. 24).…”

Section: General Genoarchitectural Of the Prethalamusmentioning

confidence: 68%

“…As indicated above, the PThE mantle massively expresses TBR1, which also appears expressed less densely, though slightly more ventrally, in the central and ventral parts of the alar hypothalamic paraventricular area (Figure 1c). However, the chicken data of Alonso et al (2020; also unpublished experimental fate‐mapping data) suggest that the paraventricular Tbr1 ‐positive cells are tangentially migrated eminential ones.…”

Section: Discussionmentioning

confidence: 98%

“…The underlying subparaventricular area is caudally contiguous with the likewise Dlx ‐positive RLi and ZLR complex (Figure 1d,e; we had to modify this notion, since in earlier accounts we wrongly interpreted that the incertal prethalamus was continuous with the subparaventricular hypothalamus). Dorsally to the paraventricular nucleus, the PThE limits rostrally with amygdalar and hippocampal telencephalic domains (Alonso et al, 2020; Puelles, Martinez‐de‐la‐Torre, Martinez, Watson, & Paxinos, 2019; figs. 4, 11 and 12).…”

Section: Discussionmentioning

confidence: 99%

“…9). The apparent progressive “vanishing” of the PThE also relates to the existence of various tangential migrations of PThE cells into hypothalamic and telencephalic regions (Abellán et al, 2010; Alonso et al, 2020; Huilgol et al, 2013; Meyer, 2010; Meyer, Perez‐Garcia, Abraham, & Caput, 2002; Roy, Gonzalez‐Gomez, Pierani, Meyer, & Tole, 2014; Ruiz‐Reig et al, 2017; Takiguchi‐Hayashi et al, 2004; Tissir et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

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LacZ‐reporter mapping ofDlx5/6expression and genoarchitectural analysis of the postnatal mouse prethalamus

Puelles

Dı́az

Stühmer

et al. 2020

J of Comparative Neurology

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We present here a thorough and complete analysis of mouse P0-P140 prethalamic histogenetic subdivisions and corresponding nuclear derivatives, in the context of local tract landmarks. The study used as fundamental material brains from a transgenic mouse line that expresses LacZ under the control of an intragenic enhancer of Dlx5 and Dlx6 (Dlx5/6-LacZ). Subtle shadings of LacZ signal, jointly with pan-DLX immunoreaction, and several other ancillary protein or RNA markers, including Calb2 and Nkx2.2 ISH (for the prethalamic eminence, and derivatives of the rostral zona limitans shell domain, respectively) were mapped across the prethalamus. The resulting model of the prethalamic region postulates tetrapartite rostrocaudal and dorsoventral subdivisions, as well as a tripartite radial stratification, each cell population showing a characteristic molecular profile. Some novel nuclei are proposed, and some instances of potential tangential cell migration were noted.

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Section: General Genoarchitectural Of the Prethalamusmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

LacZ‐reporter mapping ofDlx5/6expression and genoarchitectural analysis of the postnatal mouse prethalamus

Puelles

Dı́az

Stühmer

et al. 2020

J of Comparative Neurology

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“…The amygdalar pallial field in addition contacts the subpallium (its striatal, pallidal and diagonal domains, where central, medial and anterior amygdala subpallial domains arise; Puelles et al 2013Puelles et al , 2016b). The pallial amygdala also contacts caudally the prethalamic eminence (rostrodorsal diencephalon; Puelles et al 2019;Alonso et al 2020). These multiple planar relationships still need to be examined in more detail to assess their relevance for causal developmental explanation of amygdalar pattern.…”

Section: Introductionmentioning

confidence: 99%

Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression

Garcı́a-Calero

Puelles

2021

Brain Struct Funct

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The amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field external to the allocortical ring, and subdivided it in five major radial domains called lateral, basal, anterior, posterior and retroendopiriform units. The anterior radial unit, whose cells typically express the Lhx9 gene (see molecular profile in Garcia-Calero et al. 2020), is located next to the pallial/subpallial boundary. This radial domain shows massive radial translocation and accumulation of its derivatives into its intermediate and superficial strata, with only a glial palisade representing its final periventricular domain. To better understand the development of this singular radial domain, not described previously, we followed the expression of Lhx9 during mouse amygdalar development in the context of the postulated radial subdivisions of the pallial amygdala and other telencephalic developmental features.

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A novel telencephalon‐opto‐hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala

et al. 2021

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Deficits in social cognition and behavior are a hallmark of many psychiatric disorders. The medial extended amygdala, including the medial amygdala and the medial bed nucleus of the stria terminalis, is a key component of functional networks involved in sociality. However, this nuclear complex is highly heterogeneous and contains numerous GABAergic and glutamatergic neuron subpopulations. Deciphering the connections of different neurons is essential in order to understand how this structure regulates different aspects of sociality, and it is necessary to evaluate their differential implication in distinct mental disorders. Developmental studies in different vertebrates are offering new venues to understand neuronal diversity of the medial extended amygdala and are helping to establish a relation between the embryonic origin and molecular signature of distinct neurons with the functional subcircuits in which they are engaged. These studies have provided many details on the distinct GABAergic neurons of the medial extended amygdala, but information on the glutamatergic neurons is still scarce. Using an Otp‐eGFP transgenic mouse and multiple fluorescent labeling, we show that most glutamatergic neurons of the medial extended amygdala originate in a distinct telencephalon‐opto‐hypothalamic embryonic domain (TOH), located at the transition between telencephalon and hypothalamus, which produces Otp‐lineage neurons expressing the telencephalic marker Foxg1 but not Nkx2.1 during development. These glutamatergic cells include a subpopulation of projection neurons of the medial amygdala, which activation has been previously shown to promote autistic‐like behavior. Our data open new venues for studying the implication of this neuron subtype in neurodevelopmental disorders producing social deficits.

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Longitudinal developmental analysis of prethalamic eminence derivatives in the chick by mapping of Tbr1 in situ expression

Cited by 18 publications

References 92 publications

LacZ‐reporter mapping ofDlx5/6expression and genoarchitectural analysis of the postnatal mouse prethalamus

LacZ‐reporter mapping ofDlx5/6expression and genoarchitectural analysis of the postnatal mouse prethalamus

Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression

A novel telencephalon‐opto‐hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala

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