2021
DOI: 10.1101/2021.10.08.463649
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Longitudinal dynamics of human B-cell response at single-cell level in response to Tdap vaccination

Abstract: Adaptation of the immune system to mount an adequate immune response against pathogens is a crucial function of the adaptive immune system. To better characterize a successful vaccination response, we performed longitudinal (days 0, 5, 7, 10, and 14 after Boostrix vaccination) analysis of the single-cell transcriptome as well as the B-cell receptor (BCR) repertoire (scBCR-rep) in plasma cells of an immunized donor and compared it with baseline B cell characteristics as well as flow cytometry findings. Based on… Show more

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