Longitudinal erythronychia: Suggestions for evaluation and management

Jellinek, Nathaniel J.

doi:10.1016/j.jaad.2009.10.047

Cited by 67 publications

(78 citation statements)

References 32 publications

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“…Onychopapilloma is a benign nail bed tumor 10,11 first reported in 1995 by Baran and Perrin. 12 It was originally described as a distal subungual keratosis with multinucleated cells but this terminology was replaced by onychopapilloma in 2000.…”

Section: Onychopapillomamentioning

confidence: 99%

“…Single band of longitudinal erythronychia, 10,11,14 which is characterized by a linear red streak affecting a single nail. 10,15 The band of longitudinal erythronychia may or may not be associated with distal splitting of the nail plate.…”

Section: Onychopapillomamentioning

confidence: 99%

“…After avulsion of the nail plate, the onychopapilloma can be visualized as a subtle, erythematous bulge in the distal nail matrix with a longitudinal ridge in the nail bed, as well as distal nail bed hyperkeratosis. 11 Histologic changes include acanthosis and papillomatosis principally in the distal epithelium of the nail bed. 10,14 Differential diagnoses of longitudinal erythronychia include glomus tumor, Bowen disease, verruca, Darier disease, benign vascular proliferations, lichen planus, and melanoma.…”

Section: Onychopapillomamentioning

confidence: 99%

“…10,14 Differential diagnoses of longitudinal erythronychia include glomus tumor, Bowen disease, verruca, Darier disease, benign vascular proliferations, lichen planus, and melanoma. 11 However, the presence of localized longitudinal erythronychia associated with a keratotic mass under the distal nail plate is diagnostic for onychopapilloma.…”

Section: Onychopapillomamentioning

confidence: 99%

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Tips to Diagnose Uncommon Nail Disorders

Schneider

Tosti

2015

Dermatologic Clinics

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Section: Onychopapillomamentioning

confidence: 99%

Section: Onychopapillomamentioning

confidence: 99%

Section: Onychopapillomamentioning

confidence: 99%

Section: Onychopapillomamentioning

confidence: 99%

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Tips to Diagnose Uncommon Nail Disorders

Schneider

Tosti

2015

Dermatologic Clinics

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“…Кроме того, эритронихия характерна для полицитемии, системной красной волчанки, вторич-ного амилоидоза, болезни Дарье, может быть при-знаком новообразований в области ногтевого ложа (гемангиома, гломусная опухоль, энхондрома и др.) [18]. Этот симптом бывает выражен при заболева-ниях системы кроветворения, васкулитах и наруше-ниях коагуляции и гемостаза (например, гемофилия, тромбоцитопения, прием антикоагулянтов) [6,21].…”

Section: проявления од при заболеваниях различных оранов и системunclassified

Dystrophic changes nail plates in general clinical practice

Bolotna¹,

Sarian²

2015

Shidnoevr. z. vnutr. simejnoi med.

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Multiple Onychopapillomas and BAP1 Tumor Predisposition Syndrome

Lebensohn,

Ghafoor,

Bloomquist

et al. 2024

JAMA Dermatol

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ImportanceBRCA1-associated protein (BAP1) tumor predisposition syndrome (TPDS) is a cancer genodermatosis associated with high risk of uveal and cutaneous melanoma, basal cell carcinoma, and multiple internal malignant neoplasms, including mesothelioma and renal cell carcinoma. Early detection of the syndrome is important for cancer surveillance and genetic counseling of family members who are at risk.ObjectiveTo determine the prevalence of nail abnormalities in individuals with pathogenic germline variants in BAP1.Design, Setting, and ParticipantsIn this prospective cohort study, individuals who were known carriers of pathogenic BAP1 germline variants were consecutively enrolled between October 10, 2023, and March 15, 2024. Dermatologic evaluation for nail abnormalities was performed, including a history of nail abnormalities and associated symptoms, physical examination, medical photography, and nail biopsy for histopathology. This was a single-center study conducted at the National Institutes of Health Clinical Center.Main Outcomes and MeasuresPrimary outcomes were the prevalence and spectrum of nail changes and histopathologic characterization.ResultsAmong 47 participants (30 female [63.8%]; mean [SD] age, 46.4 [15.1] years) ranging in age from 13 to 72 years from 35 families, nail abnormalities were detected in 41 patients (87.2%) and included leukonychia, splinter hemorrhage, onychoschizia, and distal nail hyperkeratosis. Clinical findings consistent with onychopapilloma were detected in 39 patients (83.0%), including 35 of 40 individuals aged 30 years or older (87.5%). Nail bed biopsy was performed in 5 patients and was consistent with onychopapilloma. Polydactylous involvement with onychopapillomas was detected in nearly all patients who had nail involvement (38 of 39 patients [97.4%]).Conclusions and RelevanceThis study found that BAP1 TPDS was associated with a high rate of nail abnormalities consistent with onychopapillomas in adult carriers of the disease. Findings suggest that this novel cutaneous sign may facilitate detection of the syndrome in family members who are at risk and patients with cancers associated with BAP1 given that multiple onychopapillomas are uncommon in the general population and may be a distinct clue to the presence of a pathogenic germline variant in the BAP1 gene.

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Longitudinal erythronychia: Suggestions for evaluation and management

Cited by 67 publications

References 32 publications

Tips to Diagnose Uncommon Nail Disorders

Tips to Diagnose Uncommon Nail Disorders

Dystrophic changes nail plates in general clinical practice

Multiple Onychopapillomas and BAP1 Tumor Predisposition Syndrome

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