Adolescent depression has become epidemic in the United States, with statistics showing that one in five adolescents may suffer from depression (Brent and Birmaher in N Engl J Med 347(9), 2002). This article examines adolescent depression from a psychodynamic perspective, and identifies the psychodynamics of adolescent depression as the affective correlates that stem from unresolved developmental conflicts, issues of separation/ individuation, the search for identity and the development of the true self. This article presents wilderness therapy as a holistic intervention which can be used to address the intrapsychic, developmental and relational factors that give rise to adolescent depression. Wilderness therapy is a modality of mental health treatment that takes place outdoors and utilizes challenge and adventure, group work and other structured clinical interventions. A clinical case study presents wilderness therapy as an effective intervention for adolescent depression that can promote positive self-image and enhanced coping skills, and discusses limitations and implications for social work practice.