Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the Cardiovascular Risk in Young Finns Study

Abstract

Oxidative reactions are thought to play a role in the inflammatory condition called fatty liver. It is unclear whether oxidized lipoprotein lipids or proteins are associated with future fatty liver. In the Cardiovascular Risk in Young Finns Study, we determined the circulating levels of LDL and HDL oxidized lipids and studied their associations with fatty liver assessed by ultrasonography. There were 1286 middle-aged subjects with normal liver and 288 subjects with fatty liver. Analysis of oxidized lipids consisted of conjugated dienes in isolated HDL (oxHDLlipids) and LDL (oxLDLlipids). Oxidized LDL was also measured with a method based on antibodies against oxidized apolipoprotein B (oxLDLprot). After adjustment for age, sex, leisure-time physical activity, body mass index, alcohol intake, smoking, serum LDL and HDL cholesterol as well as particle concentrations, participants with elevated oxLDLlipids (odds ratio for 1-SD change in oxLDLlipids = 1.27, p =0.011) had an increased risk for fatty liver. Similarly, a high oxidation score (oxLDLlipids + oxLDLprot) was directly associated with fatty liver (odds ratio=1.34, p = 0.012). The strongest direct association was seen with a high oxLDLlipids/oxHDLlipids ratio (odds ratio=1.49, p = 0.001). These data suggest that oxidized lipoprotein lipids are linked with the risk of fatty liver in middle-aged adults.

Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation includingCitrus bergamia, in subjects with moderate cardiometabolic risk factors

“…Ours is the first study to report a favorable effect of a BFE formulation on oxLDL and oxLDL/HDL, which are considered more predictive of both cardiovascular and diabetic risk than traditional lipid or glycemic markers (Johnston et al 2006;Kaikkonen et al 2016;Mascarenhas-Melo et al 2013;Mitra et al 2011b). Decreases in both biomarkers trended to greater efficacy and statistical significance in the subgroup relative to all subjects, decreasing from −10% to −19% and from −17% to −25%, respectively.…”

Association between circulating oxidized low‐density lipoprotein and atherosclerotic cardiovascular disease

“…Apart from ASCVD, circulating ox-LDL was also reported to be associated with diabetes, 40 , 41 metabolic syndrome, 42 obesity, 41 and fatty liver, 43 which may increase the risk of ASCVD.…”

Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study

“…Nozomu Kono, et al . indicated that Lp-PLA 2 was protective against ox-LDL-induced hepatic injury, which is regarded as a leading cause of NAFLD 15 , 16 . In addition, Stanislav, et al .…”