Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration

Chen, Katherine G; Alvarez, Jason; Yazdanie, Mohammad; Papudesu, Chandana; Wong, Wai T.; Wiley, Henry; Keenan, Tiarnán D L; Chew, Emily Y.; Ferris, Frederick L.; Cukras, Catherine A

doi:10.1016/j.ophtha.2018.09.039

Cited by 49 publications

(76 citation statements)

References 44 publications

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“…The results reported by Chen et al 1 have several levels of significance. For AMD outcome measures, rod-mediated functions continue to merit attention, especially if compared with cone-mediated vision, which also receives retinoids through the Müller glia.…”

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confidence: 93%

“…Findings collectively document the fundamental responsiveness of RMDA to the natural history of early and intermediate AMD. As the authors discuss, 1 good testeretest repeatability is established already for RMDA. What barriers remain to using RMDA as a functional end point in AMD trials?…”

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confidence: 95%

“…Chen et al 1 (see page 856) provide important new information strengthening the suitability of rod-mediated dark adaptation (RMDA) as an early-to-intermediate AMD outcome measure. Results substantiate prior evidence that intermediate AMD eyes both progressed and exhibited further delay in RMDA over 2 years 2 and extended the earlier study by demonstrating that RMDA slowing over 4 years was worse in eyes with severest disease at baseline and at the 4-year follow-up.…”

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confidence: 99%

“…What barriers remain to using RMDA as a functional end point in AMD trials? The test protocol used in this study 1 and other investigators 7 is 20 minutes in duration, which some may consider long, but it is similar or in some cases even shorter than that for microperimetry. Microperimetry uses an extensive test target grid and requires preadaptation to the background light level.…”

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confidence: 99%

“…To these known contributors to RMDA dynamics, based on the findings of Chen et al, 1 we now also add SDDs, which are solid space-filling extracellular deposits between the RPE and photoreceptors revealed by OCT-based imaging within the last decade. 3 Subretinal drusenoid deposits are critically positioned to impact photoreceptor health as well as retinoid transfer, because lesions directly contact the affected cells.…”

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confidence: 99%

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Rod-Mediated Dark Adaptation as a Suitable Outcome for Early and Intermediate Age-Related Macular Degeneration

Curcio¹,

Owsley²

2019

Ophthalmology

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confidence: 93%

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confidence: 95%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Rod-Mediated Dark Adaptation as a Suitable Outcome for Early and Intermediate Age-Related Macular Degeneration

Curcio¹,

Owsley²

2019

Ophthalmology

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Clustering Disease Trajectories in Contrastive Feature Space for Biomarker Proposal in Age-Related Macular Degeneration

Holland,

Leingang,

Holmes

et al. 2023

Lecture Notes in Computer Science

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Additional measures of macular function beyond visual acuity

Ríos,

Lövestam-Adrian,

Plainis

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose Visual function is a complex process in which external visual stimuli are interpreted. Patients with retinal diseases and prolonged follow-up times may experience changes in their visual function that are not detected by the standard visual acuity measure, as they are a result of other alterations in visual function. With the advancement of different methods to evaluate visual function, additional measurements have become available, and further standardization suggests that some methods may be promising for use in clinical trials or routine clinical practice. The objectives of this article are to review these additional measurements and to provide guidance on their application. Methods The Vision Academy’s membership of international retinal disease experts reviewed the literature and developed consensus recommendations for the application of additional measures of visual function in routine clinical practice or clinical trials. Results Measures such as low-luminance visual acuity, contrast sensitivity, retinal fixation and microperimetry, and reading performance are measures which can complement visual acuity measurements to provide an assessment of overall visual function, including impact on patients’ quality of life. Measures such as dark adaptation, color vision testing, binocular vision testing, visual recognition testing, and shape discrimination require further optimization and validation before they can be implemented in everyday clinical practice. Conclusion Additional measurements of visual function may help identify patients who could benefit from earlier diagnosis, detection of disease progression, and therapeutic intervention. New and additional functional clinical trial endpoints are required to fully understand the early stages of macular disease, its progression, and the response to treatment.

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Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration

Cited by 49 publications

References 44 publications

Rod-Mediated Dark Adaptation as a Suitable Outcome for Early and Intermediate Age-Related Macular Degeneration

Rod-Mediated Dark Adaptation as a Suitable Outcome for Early and Intermediate Age-Related Macular Degeneration

Clustering Disease Trajectories in Contrastive Feature Space for Biomarker Proposal in Age-Related Macular Degeneration

Additional measures of macular function beyond visual acuity

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