Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

Sakr, Carine J.; Leonard, Robin C.; Kreckmann, Kim H.; Slade, Martin D.; Cullen, Mark R.

doi:10.1097/jom.0b013e318124a93f

Cited by 150 publications

(127 citation statements)

References 30 publications

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“…As shown in Supplementary Table S3, previous studies have investigated the associations between serum lipids and PFAAs concentrations (Emmett et al, 2006;Sakr et al, 2007a;Sakr et al, 2007b;Frisbee et al, 2010a;Nelson et al, 2010;Eriksen et al, 2013;Fisher et al, 2013). However, those data are not always consistent.…”

Section: Discussionmentioning

confidence: 66%

“…One cross-sectional study carried out among occupational population with a much higher exposure level observed a modest but statistically significant, positive relationship between serum PFOA and TC, LDLC, for each increase in 1 ng/mL in serum PFOA, TC and LDLC increases by 0.10 Â 10 À 3 and 0.07 Â 10 À 3 mmol/L, respectively (Sakr et al, 2007a). In a longitudinal study, Sakr et al (2007b) found serum PFOA was positively associated with TC, with an increase of 0.03 Â 10 À 3 mmol/L of cholesterol for each 1 ng/mL increase in PFOA. Another longitudinal study investigated the association between within-individual changes in serum PFAAs and changes in serum lipid levels; they found that there was a tendency for people with greater declines in serum PFOA to have greater LDLC decrease.…”

Section: Discussionmentioning

confidence: 99%

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Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tPerfluoroalkyl acids (PFAAs) have been used in a variety of products for many years and have been detected worldwide in human serum. Previous studies have suggested the potential effects of PFAAs on serum lipids. To investigate the associations between serum concentrations of PFAAs and serum lipid levels, 133 participants were randomly selected from the people coming for health check-up in Yuanyang Red Cross Hospital of Henan, China. Linear regression analysis revealed that perfluoro-octanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), with a median concentration of 1.43, 0.37, and 0.19 ng/mL, respectively, were positively associated with total cholesterol (TC). Those in the highest quartile of PFOA exposure had ln-TC levels 0.24 mmol/L higher than those in the lowest quartile. For PFNA and PFDA, effect estimates were 0.25 and 0.16 mmol/L, respectively. A positive association between high-density lipoprotein cholesterol (HDLC) and PFDA was found, and there was a 0.18 mmol/L increase of HDLC for the top PFDA quartile compared with the lowest quartile. PFOA and PFNA were positively associated with low-density lipoprotein cholesterol (LDLC). Ln-LDLC levels of people in both top PFOA and PFNA quartiles were 0.33 mmol/L higher than those in the lowest quartiles. Logistic regression analysis indicated that increased PFOA and PFOS quartiles were positively associated with an increased risk of abnormal TC and LDLC when controlling for no confounding factors.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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“…Exposure of Sprague-Dawley rats to PFOS and PFOA at a dose of 20 mg/kg resulted in hepatomegaly and severe histological changes of the liver, such as fatty degeneration, hepatocytic necrosis, and inflammatory cell infiltration 5) . Positive correlations of serum levels of PFOA with serum liver enzymes (γ -GTP, GOT or GPT) have been reported in several studies on fluorochemical workers with heavy exposure to PFOA or its related substance 32,33) but not in others 34,35) . Positive correlations were also observed between serum levels of PFOA or PFOS and hepatic enzymes (γ -GTP and/or GPT) in populations of the U.S. with high or background exposure to these PFCs 36,37) .…”

Section: Discussionmentioning

confidence: 99%

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

Yamaguchi

Arisawa

Uemura

et al. 2013

Journal of Occupational Health

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PFOA, with medians being highest in the Tokai/Hokuriku/ Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan. (J Occup Health 2013; 55: 184−194) Key words: Blood, Fish intake, Perfluorooctanesulfonate (PFOS), Perfluorooctanoate (PFOA), Serum liver enzymes Perfluorochemicals (PFCs) are man-made chemical substances containing C-C and C-F bonds. PFCs are extremely resistant to degradation, and accumulate in the environment. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are two of the main PFCs. PFOS and PFOA have both hydrophilic and lipophilic properties. PFOS bioaccumulates in animal tissues through the food web 1) , and exposure to PFOA occurs in part through drinking water and beverages 2) . The geometric mean elimination half-lives of PFOS and PFOA from human serum are approximately 4.8 and 3.5 years, respectively 3) . Recently, it has been reported that PFOS and PFOA have toxic effects on wildlife and humans. The toxicity includes neurobehavioral defects 4) , hepatotoxicity 5) , immune toxicity and carcinogenicity 6) . A reduction in human exposure to PFCs has been reported following the phasing-out of perfluorosulfonyl-based compounds and the Environmental Protection Agency's program The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ -GTP, GOT, and GPT) and ω -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω -3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and

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“…Some epidemiological studies have shown positive associations between PFOA and lipids in general human populations. For example, in occupationally exposed employees, increased PFOA was associated with increased total cholesterol and triglycerides Sakr et al 2007). Recently, a much larger study of adults from environmentally exposed and adjacent communities reported a positive association between PFOA and total and low-density lipoprotein cholesterol, and a less clear association of PFOA with triglycerides (Steenland et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein

Sheng

Liu

et al. 2014

Arch Toxicol

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Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

Abstract: These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

Cited by 150 publications

References 30 publications

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein

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