Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras, Ana B.; Pardo, María; Roca-Rivada, Arturo; Navas-Carretero, Santiago; Zulet, M. Ángeles; Martínéz, J. Alfredo; Casanueva, Felipe F.

doi:10.1002/ajhb.22493

Cited by 129 publications

(146 citation statements)

References 46 publications

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“…With these mechanisms, irisin hormone appeared to be anti-obesity hormone. Indeed, the studies conducted later have determined that irisin levels were higher in the obese patients compared to the healthy control group (Crujeiras et al 2014). Th e association between T2DM and iris levels is oft en being questioned in recent studies.…”

Section: Discussionmentioning

confidence: 98%

“…Because previous studies have shown that there is a positive correlation between the blood glucose level and irisin (Liu et al 2013). In addition, another study has suggested that Adj R 2 = 0.344. p<0.001* ‡ Age, sex, BMI and disease duration are adjusted Abbreviations: DM -diabetes mellitus; BMI -body mass index; HbA1C -glycosylated hemoglobin A1C; FBG -fasting blood glucose; Anti-GAD -anti-glutamic acid decarboxylase; IAA -insulin auto-antibody; CRP -C-reactive protein irisin increases as a compensatory answer for hyperglycemia (Crujeiras et al 2014). Also the determination of HbA1c as an independent risk factor for irisin, in the multivariate regression analysis, supports our thesis.…”

Section: Discussionmentioning

confidence: 99%

“…Irisin levels have oft en been determined to be decreased in the type 2 diabetes mellitus (T2DM) (Choi et al 2013) and increased in obesity (Crujeiras et al 2014) and insulin resistance (Staiger et al 2013). It has recently been reported that irisin levels increase in T1DM patients (Espes et al 2015).…”

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confidence: 99%

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Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş

Arikan

Erdoğan

et al. 2017

Endocrine Regulations

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Objective. Th e aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the infl ammation and autoimmunity.Methods. Th is study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient fi les. Serum irisin levels were measured by ELISA kit.Results. Th e median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic infl ammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as infl ammation and autoimmunity can be eff ective in the synthesis of irisin.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş

Arikan

Erdoğan

et al. 2017

Endocrine Regulations

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“…But there were significant higher differences between obese and non-obese groups both control and PCOS this explained the correlation with BMI. To date, there have been reports of the positive [21,[45][46][47][48], negative [24,[49][50][51] and no correlations [44,45,52,53] between serum irisin and body mass index (BMI). Decreased levels of circulating irisin have been found in T2DM patients compared with non-diabetic controls [46].…”

Section: Discussionmentioning

confidence: 99%

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Ali

Al-nuaimi

Al-Musawi³

2016

Int J Pharm Pharm Sci

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Objective: This study was aimed to evaluate the effect of serum leptin level on irisin level in relation to glucose homeostasis that to be associated with hormonal changes (Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Prolactin (PRL), Testosterone (TES)) in obese and nonobese women with polycystic ovary syndrome (PCOS). Methods:Fifty women with polycystic ovaries syndrome (PCOS) and thirty-four apparently healthy control women with regular menstruation (28±2days) were included in this study both of PCOS patients and controls were divided into sub-groups according to their body mass index (BMI) into: twenty-five obese (BMI ≥30) with (BMI= 35.934±0.746) and another twenty-five non-obese polycystic ovaries syndrome women (BMI=25.074±0.456). Whereas, controls were divided as seventeen obese (BMI= 37.140±1.470) and seventeen non-obese (BMI= 25.022±0.683) healthy control women with regular menstruation with an age range (20-40 y) and BMI matching that of the patient groups. Venous blood samples were collected to measure serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH, prolactin (PRL), total testosterone (TES), thyroid stimulating hormone (TSH). As well as, fasting glucose, irisin, leptin, and insulin. Besides, estimating Insulin Resistance (HOMA-IR) index, β-cell function was determined using the Homeostasis Model Assessment of β-cell function (HOMA-β).Results: Serum irisin levels were not significantly different from their corresponding controls, in both obese and non-obese PCOS patients. Whereas, serum irisin levels were elevated significantly in both obese (patients and control) as compared to non-obese (patients and controls), respectively. But, serum leptin levels were significantly elevated in obese PCOS patients as compared to their corresponding control group, nonobese control, and non-obese PCOS patients. However, serum leptin levels were not significantly different in non-obese women groups, both the PCOS and controls. The irisin/insulin ratio expressed no significant variations from its corresponding control in non-obese groups. But the obese PCOS patient's values were highly significantly different as compared to their control (p<0.01). Furthermore, irisin/insulin ratio was elevated significantly in obese control as compared to non-obese patients (p = 0.001), but not with non-obese controls (p=0.114). The leptin/insulin ratio was not significantly varied in PCOS groups from their corresponding control in non-obese (p = 0.094) but in obese PCOS patients, there was significantly different as compared to its control (p = 0.01). Furthermore, leptin to insulin ratio was not significantly different between patients groups (non-obese and obese, p=0.133), nor between the studied controls (p=0.705). Conclusion:Although serum irisin levels show no significant variation in subjects in relation to PCOS condition, it seems more to be related to BMI, since it's secreted by adipocytes. And because leptin and irisin levels would be elevated in obese subjects th...

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“…In addition to the association of irisin with obesity, the association of irisin with weight loss has also been studied [33,35,36]. In a study by Crujeiras et al, insulin levels were found to be higher in obese patients and significantly correlated with weight, BMI, waist circumference, and fat mass.…”

Section: Prace Oryginalnementioning

confidence: 99%

Wpływ gastrektomii rękawkowej na poziom irisiny w surowicy pacjentów z chorobliwą otyłością

Demirpençe¹,

Yilmaz²,

Çolak³

et al. 2016

Endokrynologia Polska

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Introduction: Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG). Materials and methods: Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at three months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin, and irisin levels were measured at each visit. Results: The two groups had similar mean age and sex distribution. Serum irisin was significantly lower in the morbidly obese subjects compared with the controls (p = 0.003) and negatively correlated with BMI, body weight, insulin levels, and HOMA-IR (p = 0.006, p = 0.011, p = 0.046, p = 0.048, respectively). When the morbidly obese patients were re-evaluated three months post-SG, their weight and BMI had significantly decreased (both p = 0.001). Similarly, the insulin, HbA1c, HDL-cholesterol, and HOMA-IR values significantly decreased (p = 0.001, p = 0.028, p = 0.006, and p = 0.001, respectively). However, irisin levels remained unchanged (p = 0,267). Conclusion: Although the irisin levels were significantly lower in the morbidly obese subjects, they did not change after SG-induced weight loss.

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Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Cited by 129 publications

References 46 publications

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Wpływ gastrektomii rękawkowej na poziom irisiny w surowicy pacjentów z chorobliwą otyłością

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