Longitudinally extensive transverse myelopathy in a patient with CADASIL

Pinto, Wladimir Bocca Vieira de Rezende; Souza, Paulo Victor Sgobbi de; Oliveira, Acary Souza Bullé

doi:10.1590/0004-282x20150096

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Oligoclonal bands in the cerebrospinal fluid (CSF), a characteristic finding in MS, are extremely uncommon in CADA-SIL, but they have been reported [22,23] . The occurrence of spinal cord lesions, especially longitudinal ones, are exceedingly rare in CADASIL and may be due to ischemia [24] but, when present, they evoke a diagnostic challenge [25] . In one family with CADASIL, 3 members presented with cord lesions in the posterocentral area, cerebral lesions in locations compatible with both demyelination and typical CADASIL, positive antinuclear antibodies and CSF oligoclonal bands [26] .…”

Section: Possible Comorbidity Of Ms and Cadasilmentioning

confidence: 99%

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy vs. multiple sclerosis. Either one or sometimes both?

Paraskevas¹,

Constantinides²,

Kapaki³

2018

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), is the most common cause of inherited cerebral small vessel disease, inherited stroke and inherited vascular dementia. It is not infrequent for CADASIL to be mistaken and mistreated for multiple sclerosis (MS). A much less frequent but existing scenario is the co-occurrence of CADASIL and MS (or MS-like inflammatory condition). Such patients may present with spinal cord lesions, brain or spinal cord enhancing lesions, positive oligoclonal bands and high IgG index in the cerebrospinal fluid and good response to corticosteroids or immunomodulating treatments. CADASIL through various mechanisms may trigger or modulate autoimmune reactions, and either be complicated by an inflammatory component or cause an MS-like disorder.

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Section: Possible Comorbidity Of Ms and Cadasilmentioning

confidence: 99%

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy vs. multiple sclerosis. Either one or sometimes both?

Paraskevas¹,

Constantinides²,

Kapaki³

2018

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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

Donato

Bianchi

Stefano

et al. 2017

BMC Med

237

175

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients.

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Longitudinally extensive transverse myelopathy in a patient with CADASIL

Cited by 2 publications

References 3 publications

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy vs. multiple sclerosis. Either one or sometimes both?

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy vs. multiple sclerosis. Either one or sometimes both?

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

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