2022
DOI: 10.1186/s13613-022-01024-6
|View full text |Cite
|
Sign up to set email alerts
|

Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Abstract: Background Fluid overload is a risk factor for organ dysfunction and death in intensive care unit (ICU) patients, but no guidelines exist for its management. We systematically reviewed benefits and harms of a single loop diuretic, the predominant treatment used for fluid overload in these patients. Methods We conducted a systematic review with meta-analysis and Trial Sequential Analysis (TSA) of a single loop diuretic vs. other interventions report… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
15
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 13 publications
(16 citation statements)
references
References 72 publications
0
15
0
Order By: Relevance
“…Essential findings were an increase in ventilator-free days and a decrease in days in the ICU in the de-resuscitative and conservative groups (14). The largest systematic review on loop diuretics in ICU patients with fluid overload showed no difference in mortality in patients treated with loop diuretics versus placebo/no intervention (13).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Essential findings were an increase in ventilator-free days and a decrease in days in the ICU in the de-resuscitative and conservative groups (14). The largest systematic review on loop diuretics in ICU patients with fluid overload showed no difference in mortality in patients treated with loop diuretics versus placebo/no intervention (13).…”
Section: Discussionmentioning
confidence: 99%
“…Loop diuretics are commonly applied to treat fluid overload in the ICU (12), but no solid evidence exists for this practice (13). Different strategies for minimization of fluid overload have been investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Furosemide is the most frequently used agent in the treatment 23,39 . No guidelines for treating fluid accumulation in the general adult intensive care population exist and the evidence for using loop diuretics is sparce 22 . We want to investigate goal directed fluid removal in adult ICU patients with moderate to severe fluid overload with furosemide versus placebo and assess benefits and harms.…”
Section: Discussionmentioning
confidence: 99%
“…Studies investigating strategies of restrictive fluid therapy and/or diuretics in ICU patients with fluid overload have found conflicting results with regards to mortality 19–21 . A systematic review of randomised clinical trials (RCT) in ICU patients with fluid overload found inconclusive evidence on the effects of loop diuretics versus placebo/no intervention on mortality 22 …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation