Loop Extrusion Machinery Impairments in Models and Disease
Anastasiya Ryzhkova,
Ekaterina Maltseva,
Nariman Battulin
et al.
Abstract:Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing the three-dimensional structure of chromatin, facilitating key processes such as gene regulation, DNA repair, and chromosome segregation. This review explores the molecular mechanisms and biological significance of SMC-mediated loop extrusion complexes, including cohesin, condensins, and SMC5/6, focusing on their structure, their dynamic function during the cell cycle, and their impact on chromatin architecture. We discuss … Show more
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