Losartan prevents mesenteric vascular bed alterations in high-fat diet fed rats

Lee, Hyun Jae; Cantú, Silvana M.; Primo, María Álvarez; Peredo, Horacio A.; Donoso, Alfredo O.; Puyó, Ana María; Choi, Marcelo Roberto

doi:10.1016/j.artere.2021.01.001

Cited by 1 publication

(1 citation statement)

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“…There is a consensus that PVAT releases anti-contractile factors, based on early studies performed 30 years ago [ 41 ] and discussed in a number of review articles [ 26 , 27 , 42 - 44 ] . While many studies into the effects of PVAT have been performed in rats or other experimental species [ 41 , 45 , 46 ] , there are those that have been performed specifically on vessels used as bypass conduits in CABG. In general, these studies focus on the two main vessels used for myocardial revascularization, ITA [ 39 , 47 ] and SV [ 26 - 28 , 48 ] .…”

Section: Discussionmentioning

confidence: 99%

Towards Endoscopic No-Touch Saphenous Vein Graft Harvesting in Coronary Bypass Surgery

Kopjar

Dashwood

2022

Braz J Cardiovasc Surg

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The saphenous vein is the most used conduit for coronary artery bypass surgery. However, the patency rate of this graft is inferior to the internal thoracic artery patency rate, which is the gold standard. Using the conventional technique, the saphenous vein is harvested via a large open incision and excised in such a way that causes both vascular damage and wound healing complications. Consequently, vein graft patency and surgical site infection may be compromised. Graft patency is markedly improved when the saphenous vein is harvested atraumatically with minimal damage and with surrounding cushion of perivascular fat intact. However, despite the improved graft performance, wound healing complications and infection remain a problem. Although wound healing complication is reduced when using endoscopic vein harvesting, there may be a negative impact on graft performance. This is due to vascular damage associated with application of forces to the vein that are usually avoided in open vein harvesting, including traction, adventitial stripping, and venous compression. There is evidence to suggest that improved patency of endoscopically harvested saphenous veins is associated with the surgeon’s experience of the technique. Recently, endoscopic methods of harvesting have been described where the saphenous vein is removed intact and with minimal vascular damage caused. In addition, wound healing complications, infection, and scarring are reduced. While the effect of these techniques on vein graft patency have yet to be reported, the ability to obtain a superior graft with reduced wound complications will be of great benefit to patients undergoing coronary revascularization procedures.

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