Loss of activity-dependent Arc gene expression in the retrosplenial cortex after hippocampal inactivation: Interaction in a higher-order memory circuit

Kubík, Štěpán; Miyashita, Teiko; Kubik-Zahorodna, Agnieszka; Guzowski, John F.

doi:10.1016/j.nlm.2011.10.004

Cited by 33 publications

(43 citation statements)

References 45 publications

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“…Moreover, in the adjacent brain regions that were not targeted for inactivation, Arc expression in the MUS infused hemisphere was significantly greater than the caged control (T [9] = 4.55, p < 0.01; one sample). The observation that MUS blocked Arc expression is consistent with previous data (Kubik, Miyashita, Kubik-Zahorodna, and Guzowski, 2012). Moreover, the reduction in activity-dependent Arc expression observed in the mPFC and PER, but not LEC, area TE or AC, of MUS infused hemispheres indicates that neural activity in the target regions of the current experiments was selectively blocked.…”

Section: Resultssupporting

confidence: 93%

Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection

Hernandez

Reasor

Truckenbrod

et al. 2017

Neurobiology of Learning and Memory

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The ability to use information from the physical world to update behavioral strategies is critical for survival across species. The prefrontal cortex (PFC) supports behavioral flexibility; however, exactly how this brain structure interacts with sensory association cortical areas to facilitate the adaptation of response selection remains unknown. Given the role of the perirhinal cortex (PER) in higher-order perception and associative memory, the current study evaluated whether PFC-PER circuits are critical for the ability to perform biconditional object discriminations when the rule for selecting the rewarded object shifted depending on the animal’s spatial location in a 2-arm maze. Following acquisition to criterion performance on an object-place paired association task, pharmacological blockade of communication between the PFC and PER significantly disrupted performance. Specifically, the PFC-PER disconnection caused rats to regress to a response bias of selecting an object on a particular side regardless of its identity. Importantly, the PFC-PER disconnection did not interfere with the capacity to perform object-only or location-only discriminations, which do not require the animal to update a response rule across trials. These findings are consistent with a critical role for PFC-PER circuits in rule shifting and the effective updating of a response rule across spatial locations.

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Section: Resultssupporting

confidence: 93%

Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection

Hernandez

Reasor

Truckenbrod

et al. 2017

Neurobiology of Learning and Memory

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“…Non-patient-based studies have demonstrated these roles to be distinct but complementary in long-term object recognition memory [16] and context-appropriate memories and behaviors [17]. HC involvement in mediating RSC contributions to navigation was also demonstrated with observations of altered neuron activity in the RSC upon HC inactivation in rats during a spatial navigation task [18]. …”

Section: Discussionmentioning

confidence: 99%

Retrosplenial Cortex (BA 29) Volumes in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease

Tan

Wong

Hodges

et al. 2013

Dement Geriatr Cogn Disord

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Background: The retrosplenial cortex (RSC) is a crucial transit region between the hippocampus and cingulate cortex and has been implicated in spatial navigation and memory. Importantly, RSC atrophy is a predilection site of Alzheimer’s (AD) pathology, but there have been no studies assessing structural changes in the RSC in behavioral variant frontotemporal dementia (bvFTD). Methods: A manual tracing method was used to calculate regional RSC volume in MRI scans from patients with bvFTD (n = 15) and AD (n = 15), as well as age- and sex-matched controls (n = 15). Results: RSC volumes were significantly reduced in the AD (p < 0.001), but not the bvFTD cohort (p > 0.1) compared to age-matched controls. RSC volumes discriminated bvFTD from AD in over 90% of the cases. Conclusion: These findings provide further evidence that RSC atrophy is specific to AD, which might explain the commonly observed spatial disorientation in this patient group.

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“…Together these findings support a specific role for RSC in establishing new associations among multiple sensory stimuli that compose a context or location. One intriguing idea that has been proposed is that the hippocampus uses such associations to form contextual and spatial representations which are subsequently incorporated into existing schemas (Eichenbaum et al, 2011; Kobayashi & Amaral, 2007; Kubik et al, 2012; Smith et al, 2011; Wolbers & Buchel, 2005). …”

Section: Functional and Anatomical Distinctions Between Rsc And Pomentioning

confidence: 99%

Toward a conceptualization of retrohippocampal contributions to learning and memory

Bucci

Robinson

2014

Neurobiology of Learning and Memory

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A wealth of data supports the notion that the hippocampus binds objects and events together in place and time. In support of this function, a cortical circuit that includes the retrosplenial cortex (RSC) and various structures in the parahippocampal region is thought to provide the hippocampus with essential information regarding the physical and temporal context in which the object/event occurs. However, it remains unclear if and how individual components of this so-called ‘where’ circuit make unique contributions to processing context-related information. Here we focus on the RSC and the postrhinal cortex (POR; homologous with parahippocampal cortex (PHC) in primates), two of the most strongly interconnected components of the where pathway and the foci of an increasing amount of recent research. Much of the behavioral evidence to date suggests that RSC and POR/PHC work closely together as a functional unit. We begin by briefly reviewing studies that have investigated the involvement of RSC and POR/PHC in contextual and spatial learning, both of which involve learning associations and relationships between the individual stimuli that compose an environment (i.e., where information). However, we propose that potential differences have been overlooked because most studies to date have relied on behavioral paradigms and experimental approaches that are not well suited for distinguishing between different aspects of information processing. We then consider the anatomical differences between RSC and POR/PHC and emerging behavioral evidence that gives rise to a working model of how these regions may differentially contribute to hippocampal-dependent learning and memory. We then discuss experimental designs and behavioral methods that may be useful in testing the model. Finally, approaches are described that may be valuable in probing the nature of information processing and neuroplasticity in the myriad of local circuits that are nested within the where pathway.

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Loss of activity-dependent Arc gene expression in the retrosplenial cortex after hippocampal inactivation: Interaction in a higher-order memory circuit

Cited by 33 publications

References 45 publications

Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection

Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection

Retrosplenial Cortex (BA 29) Volumes in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease

Toward a conceptualization of retrohippocampal contributions to learning and memory

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