Loss of basement membrane components laminin and type IV collagen parallels the progression of oral epithelial neoplasia

Tosios, Konstantinos I.; Kapranos, Nikiforos; Papanicolaou, Stavros

doi:10.1046/j.1365-2559.1998.00452.x

Cited by 43 publications

(48 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to types I and III, loss of collagen VII was detected in highly differentiated tumors, whereas lack of collagen IV was associated with decreasing tumor cell differentiation (Hagedorn et al, 1998). Reduction of type IV collagen, in particular, suggests that loss of subepithelial basement membrane continuity is associated with the progressive nature of SCC (Tosios et al, 1998). It was concluded from these studies that loss of collagen VII may serve as a potential marker for early invasive tumor growth.…”

mentioning

confidence: 92%

Adhesive Mechanisms Regulating Invasion and Metastasis in Oral Cancer

Ziober

Silverman

Kramer

2001

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

It is the relentless invasion and growth into surrounding tissue that characterize oral squamous cell carcinoma. Metastasis is perhaps the most challenging and important aspect of cancer progression, in that it generally signifies limited survival and ineffective therapy. Inherent in metastasis is invasion, the process by which cells infiltrate into adjacent tissues, degrading basement membranes and extracellular matrix and disrupting tissue architecture and sometimes organ function. The factors that regulate these processes are complex and likely involve loss of the controls that are normally in place in physiologic tissue modeling. Adhesion receptors and their ligands are important in modulating not only invasion of oral squamous cell carcinoma cells but also their survival and proliferation. Normal oral mucosal epithelial cells use integrins to maintain their anchorage to the basement membrane, whereas the formation of stratifying cell layers depends on the formation of intercellular adhesions mediated by cadherins. The process of squamous cell carcinoma invasion and dissemination requires active cell migration through the extracellular matrix with the simultaneous remodeling of intercellular adhesions. Integrins are clearly important in the invasive process, whereas intercellular adhesion receptors restrain invasion and promote a more differentiated phenotype.

show abstract

mentioning

confidence: 92%

Adhesive Mechanisms Regulating Invasion and Metastasis in Oral Cancer

Ziober

Silverman

Kramer

2001

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

show abstract

“…Los datos del estudio también concuerdan con la literatura consultada en lo referente a la localización más frecuente de las HFIOs, o sea, aquellas regiones de la mucosa oral que son expuestas frecuentemente a irritación o trauma. Tosios et al (1998) observaron resultados similares a los de este estudio, ya que las HFIOs por ellos analizadas ocurrieron en regiones como lengua, labios, mucosa yugal y gingiva.…”

Section: Discussionunclassified

Análisis Clínico e Histomorfológico de la Mucosa Oral Normal, Hiperplasia Fibroepitelial Inflamatoria Oral y Displasia Epitelial Oral

Gordón-Núñez¹,

Júnior

Lucena

et al. 2008

Int. J. Morphol.

View full text Add to dashboard Cite

GORDÓN-NÚÑEZ RESUMEN:El desarrollo del cáncer oral puede darse a partir de una mucosa aparentemente normal o a partir de una lesión precursora inicial, las cuales pueden representar pasos diferentes del proceso de carcinogénesis epitelial oral. El objetivo de este estudio fue analizar morfológicamente, a través de la técnica de la hematoxilina / eosina, la mucosa oral normal, hiperplasia fibroepitelial oral y displasia epitelial oral, con el propósito de obtener mayor información sobre las alteraciones epiteliales que pueden preceder al establecimiento y evolución de una neoplasia propiamente tal. Fue constatado que muchas de las alteraciones morfológicas observadas en las hiperplasias fibroepiteliales orales probablemente eran asociadas al proceso inflamatorio, donde es conocida la acción de mediadores químicos con capacidad de promover modificaciones morfológicas celulares y en la estructura tisular y no necesariamente representan alteraciones comunes de lesiones potencialmente malignas. Correlacionando el aspecto clínico de las lesiones con el diagnóstico histopatológico de displasia epitelial oral, no fue observada diferencia expresiva; sin embargo, la mayoría de los especimenes tuvo diagnostico clínico de leucoplasia. Se concluyó que la simple observación de las características morfológicas de las alteraciones de la mucosa oral puede ayudar el establecimiento del diagnóstico de las lesiones sufridas por la mucosa; sin embargo, no ofrecen mucha información sobre cuáles serían los eventos que llevarían al establecimiento de una determinada lesión.PALABRAS CLAVE: Mucosa oral; Hiperplasia inflamatoria oral; Displasia epitelial oral; Histomorfología. INTRODUCCIÓNAlteraciones en el equilibrio homeostático del epitelio de la mucosa oral por algún factor agresor, pueden promover el desarrollo de lesiones como la hiperplasia fibroepitelial inflamatoria oral(HFIO), la displasia epitelial oral (DEO) o, en los casos más graves, a neoplasias epiteliales (González- Moles, 1997;Montenegro & Franco, 1999).La hiperplasia representa el aumento de tamaño de un tejido o órgano debido al mayor número de células, proceso que ocurre de forma exclusiva en tejidos con capacidad mitótica, comprometiendo células biológicamente normales capaces de responder a estímulos sin perder su patrón morfológico y con preservación de la membrana basal (Zerdoner, 2003;Kumar et al., 2005).Generalmente, las alteraciones epiteliales de la HFIO son acompañadas por cambios a nivel subepitelial, tales como, hipervascularización, fibrosis e infiltrado inflamatorio predominantemente crónico (Kambic, 1997). Estas lesiones son constantemente asociadas con factores irritantes locales crónicos de baja intensidad y han sido el foco de interés de muchos estudios debido a la posibilidad de que puedan constituir entidades pre malignas; sin embargo, ese asunto es controversial (Zerdoner).

show abstract

“…Earlier studies using monoclonal or polyclonal antibodies that probably only limit detection of collagen-IV heterotrimeric molecules have variously reported BM collagen-IV macromolecules as being normally expressed, increased, greatly diminished, or even lost in oral premalignant lesions and OSCC [7,10,11,15,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…These studies also documented changes in BM collagen-IV α-chain composition in relation to progression from a preneoplastic state to cancer [5,21,23]. However, to date, there are no reports investigating the immunolocalization of BM collagen-IV α chains in conjunction with oral carcinogenesis [10,11,15,30,31]. In this study, chain-specific monoclonal antibodies against six collagen-IV α chains were used to determine the differential distribution of these proteins in archival oral mucosal specimens that showed separately and/or in contiguous manner features of normal oral mucosa, oral epithelial hyperplasia, OED, carcinoma in situ (CIS), and OSCC.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of basement membrane collagen-IV α1 to α6 chains during oral carcinogenesis

et al. 2006

View full text Add to dashboard Cite

This study aimed to resolve if basement membrane (BM) collagen alpha chains undergo remodeling during oral carcinogenesis. Using immunohistochemistry and transmission electron microscopy, we found that BMs in oral epithelial dysplasias (OED: mild, n=10; moderate, n=10; severe, n=10) and carcinoma in situ (CIS) (n=10) differed from normal mucosa (n=6) and oral epithelial hyperplasia (n=5) in showing: (1) excessive lamina densa-like material ultrastructurally, and (2) stronger immunoexpression for alpha5(IV) than for alpha1(IV), alpha2(IV), and alpha6(IV) chains-findings that implicate these molecules' role as an adhesive template for the attachment and persistence of basal dysplastic cells. Incipient loss of BM integrity in CIS, where alpha5(IV)/alpha6(IV) chains were more frequently absent than alpha1(IV)/alpha2(IV) chains, suggests that alpha(IV) network disruption is crucial for progression of dysplastic cells into the extracellular compartment, marking transition into the invasive phase. In carcinomatous BM, the disappearance of alpha(IV) chains was more severe in poorly differentiated oral squamous cell carcinoma (OSCC) (n=10) than in well-differentiated OSCC (n=10). In all samples examined, alpha3(IV) and alpha4(IV) chains were absent. These findings taken together suggest that BM collagen-IV alpha chains undergo remodeling where selective increase and loss of these molecules are probably early and late events, respectively, during progression of oral dysplasia to cancer.

show abstract

Loss of basement membrane components laminin and type IV collagen parallels the progression of oral epithelial neoplasia

Abstract: Alterations in the distribution of laminin and type IV collagen in oral premalignant and malignant lesions indicate that the loss of continuity of the subepithelial basement membrane parallels the progression of the neoplastic transformation process in oral epithelium.

Cited by 43 publications

References 33 publications

Adhesive Mechanisms Regulating Invasion and Metastasis in Oral Cancer

Adhesive Mechanisms Regulating Invasion and Metastasis in Oral Cancer

Análisis Clínico e Histomorfológico de la Mucosa Oral Normal, Hiperplasia Fibroepitelial Inflamatoria Oral y Displasia Epitelial Oral

Differential expression of basement membrane collagen-IV α1 to α6 chains during oral carcinogenesis

Contact Info

Product

Resources

About