Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells

Miao, Liyun; Huang, Zhen; Zhang, Zengli; Li, Hui; Chen, Qiufang; Yao, Chenyun; Cai, Hourong; Xiao, Yonglong; Xia, Hongping; Wang, Yongsheng

doi:10.18632/oncotarget.11630

Cited by 64 publications

(44 citation statements)

References 26 publications

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“…Recently, in lung cancer, a lncRNA expression profiling identified to FENDRR as one of the lncRNAs were differentially expressed between cancer and the adjacent normal tissues [13]. Additionally, also in lung cancer, FENDRR expression was associated with tumour migration and metastasis [14]. However, the overall contributions of FENDRR to lung cancer remain to be investigated.…”

Section: Introductionmentioning

confidence: 99%

The value of lncRNAFENDRRandFOXF1as a prognostic factor for survival of lung adenocarcinoma

et al. 2017

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It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.

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Section: Introductionmentioning

confidence: 99%

The value of lncRNAFENDRRandFOXF1as a prognostic factor for survival of lung adenocarcinoma

et al. 2017

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“…FOXF1-AS1 was associated with lung cancer cell migration and invasion by regulating EMT. Interestingly, we also found that FOXF1-AS1 might regulate EMT, stemness and metastasis of NSCLC cells via EZH2, indicating it as a therapeutic target for future treatment of NSCLC [11].…”

Section: Foxf1-as1mentioning

confidence: 67%

“…LncRNAs have been reported to be involved in multiple biological processes such as development and progression of human malignancies [7,8]. Although the potential functions of lncRNAs are still enigmatic in NSCLC, an increasing number of studies have now demonstrated that lncRNAs play a major role in development and progression of NSCLC [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Long Non-Coding RNAs in Non-Small Cell Lung Cancer: Progress and Prospects

Wu¹,

Zhao²,

Wang³

2017

Chemotherapy (Los Angel)

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Non-small cell lung cancer (NSCLC), accounts for approximately 80-85% of all lung cancer cases, is the most common cause of cancer-related death worldwide. With the advances of high-throughput sequencing, accumulating evidence suggested that the long non-coding RNA molecules, with transcripts larger than 200 nucleotides, have important roles in multiple biological processes in NSCLC. In this review, we will highlight the emerging roles of long non-coding RNAs (lncRNAs) in NSCLC, discussing both onco-lncRNAs and tumor-suppressor lncRNAs, and their potential clinical applications as diagnostic and therapeutic targets in NSCLC.

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“…These transcripts may also be further investigated as putative MDR-biomarkers. Interestingly, four of these transcripts were previously associated with the regulation of tumor cell proliferation [42], epithelial-mesenchymal transition [43], stemness [43], metastization [43][44][45], poor prognosis [44], and poor survival [46].…”

Section: Discussionmentioning

confidence: 99%

Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts

Sousa

Matthiesen

Lima

et al. 2020

Cancers

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Multidrug resistance (MDR) is one of the main limitations of cancer treatment. The overexpression of drug-efflux pumps, such as P-glycoprotein (P-gp), is a major cause of MDR. Importantly, different studies have shown that extracellular vesicles (EVs) participate in the communication between MDR cells and drug-sensitive counterparts, promoting dissemination of the MDR phenotype. In the present work, we aimed to identify RNA species present in MDR cells and in EVs released by those cells, which may be associated with the MDR phenotype. The RNA content from two pairs (leukemia and lung cancer) of MDR (P-gp overexpressing) cells and their drug-sensitive counterparts, as well as from their EVs, was analyzed by deep sequencing. Our results showed distinctive transcripts for MDR cells and their EVs, when compared with their drug-sensitive counterparts. Remarkably, two pseudogenes (a novel pseudogene and RNA 5.8S ribosomal pseudogene 2) were found to be increased in EVs released by MDR cells in both leukemia and lung cancer models. Moreover, six miRs (miR-204-5p, miR-139-5p, miR-29c-5p, miR-551b-3p, miR-29b-2-5p, and miR-204-3p) exhibited altered levels in lung cancer MDR cells and their EVs. This study provides insights into the contribution of EVs to MDR.

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Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells

Cited by 64 publications

References 26 publications

The value of lncRNAFENDRRandFOXF1as a prognostic factor for survival of lung adenocarcinoma

The value of lncRNAFENDRRandFOXF1as a prognostic factor for survival of lung adenocarcinoma

Emerging Role of Long Non-Coding RNAs in Non-Small Cell Lung Cancer: Progress and Prospects

Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts

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