Abstract:Background: Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192 was a key feature for multiple groups of CSC-positive primary HCCs. We thus aimed to investigate essential metabolic features of hepatic CSCs via using HCCs with miR-192 silencing as a model. Methods: Data integration analyses of miR-192 with metabolome and mRNA transcriptome in HCC coho… Show more
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