Low-amplitude propagated contractile waves: a relevant propulsive mechanism of human colon

Bassotti, Gabrio; Clementi, Marco; Antonelli, Elisabetta; Pelli, Maria Antonietta; Tonini, Marcello

doi:10.1016/s1590-8658(01)80133-x

Cited by 52 publications

(43 citation statements)

References 24 publications

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“…Physical activity promotes bowel movements by improving bowel activity in the large intestine [11], [34]. Nevertheless, it is difficult to quantify the physiological changes caused by physical activity, because human colonic motor activity has been insufficiently investigated [35]. In addition, physical activity may change the level of endogenous sex hormones,[36] which have been shown to regulate colonic transit time, for example, reduced progesterone level could decrease the gastrointestinal transit time [37].…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Constipation in Hong Kong Adolescents

Huang

et al. 2014

PLoS ONE

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ObjectiveTo examine the association of constipation with exercise, non-exercise physical activity, and sedentary behaviours in Hong Kong adolescents.MethodsIn 2006–2007, 42 secondary schools were randomly selected to participate in the Hong Kong Student Obesity Surveillance (HKSOS) project. A total of 33692 Form 1–7 students (44.9% boys; mean age 14.8, SD 1.9 years) completed an anonymous questionnaire on lifestyle behaviours. Constipation was defined as a frequency of evacuation of less than once every two days. Exercise (moderate-to-vigorous levels) and non-exercise physical activity (NEPA) were each considered insufficient when less than 1 hour per day, and sedentary behaviours were considered excessive when over 4 hours per day. Logistic regression was used to calculate adjusted odds ratio (AOR) for constipation in relation to exercise, NEPA, and sedentary behaviours, adjusting for potential confounders.ResultsConstipation was identified in 15.6% (95% CI 15.2% – 16.0%) of adolescents overall, 14.0% in those with sufficient exercise and 19.6% in those without. Constipation was associated with insufficient exercise (AOR 1.26, 95% CI 1.16 – 1.36), insufficient NEPA 1.21 (1.10 – 1.33) and excessive sedentary behaviours (1.25, 1.17 – 1.34). Compared with having none of the above 3 inactive behaviours, increasing AORs of constipation were observed for having 1 (AOR 1.23), 2 (AOR 1.57) and 3 (AOR 1.88) inactive behaviours (p for trend <0.001).ConclusionsConstipation was associated with insufficient physical activity and excessive sedentary behaviours among Chinese adolescents with a dose-response relation. If the association is causal, constipation could be prevented by promotion of physical activity.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Constipation in Hong Kong Adolescents

Huang

et al. 2014

PLoS ONE

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“…The majority of published studies have employed the technique of perfused tube manometry 3–7 . The bulky extracorporal apparatus precludes its use for ambulatory studies, requiring the subject to remain sedentary and be placed in the abnormal environment of the laboratory.…”

Section: Introductionmentioning

confidence: 99%

Periodic colonic motor activity identified by 24‐h pancolonic ambulatory manometry in humans

Hagger

Kumar

Benson

et al. 2002

Neurogastroenterology Motil

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The pattern of colonic motor activity in healthy humans has not been fully elucidated to date. The aim of this study was to evaluate colorectal motor activity employing 24-h ambulant pancolonic manometry. Ten healthy volunteers (6F, 4M), aged 19-31 years were studied. Motor activity was measured using two custom-made silicone coated catheters, each with five solid-state pressure transducers. No bowel preparation or sedation was used. The study period was 24 h. A total of 232 h of recording was obtained. Sixty-three high amplitude propagated contractions were observed, median six per 24-h period. Low-amplitude colonic contractile activity showed regional and diurnal variations. Frequency of contraction was highest in the right colon [median 5.26 cpm (cycles per minute)], and transverse colon and splenic flexure (median 5.15 cpm). The interval between colonic motor complexes was shortest in the transverse colon and splenic flexure. This study introduces a new technique for the evaluation of colorectal motor activity. Subjects were studied in an ambulant setting in their own environment ensuring that this method of study is as physiological as possible. This study demonstrates that colonic motor activity has two main components: high amplitude propagated contractions and low amplitude colonic contractile activity.

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“…Available data refer almost exclusively to the forceful propulsive activity, which is recognized as high-amplitude propagated contractions, the manometric equivalent of mass movements. 17 We identified the basal intraluminal pressure in the terminal colon segment with the index of resistance on the part of the smooth muscle cuff against the spontaneous evacuation of the bowel content. The pressure results from the contractile potential of both circular and longitudinal muscles in the transplant wall.…”

Section: Discussionmentioning

confidence: 99%