Low and High-Oncogenic Risk Human Papillomaviruses: Every Rule Has its Exception

Oliveira, Cristina Mendes de

doi:10.5533/2177-8264-201123402

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…They are causal agents of benign and malignant oropharyngeal-laryngeal mucosal lesions and of benign and malignant anogenital cutaneous and mucosal lesions [2, 3]. Among the various malignant neoplasms that can be caused by a persistent HPV infection, cervical cancer (CC) [2–5] is the fourth most common type of cancer in women globally (and the seventh overall), with a mortality rate of up to 50%. A large majority (around 85%) of the global burden occurs in the less developed countries of the world, where it accounts for almost 12% of all female cancers.…”

Section: Introductionmentioning

confidence: 99%

“…Human papillomavirus (HPV) is a large and assorted group of mainly sexually transmitted double-stranded DNA viruses, grouped under the Papillomaviridae family [1]. They are causal agents of benign and malignant oropharyngeal-laryngeal mucosal lesions and of benign and malignant anogenital cutaneous and mucosal lesions [2, 3]. Among the various malignant neoplasms that can be caused by a persistent HPV infection, cervical cancer (CC) [2–5] is the fourth most common type of cancer in women globally (and the seventh overall), with a mortality rate of up to 50%.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of human papillomavirus types in North and Central regions of Mexico

Luna-Aguirre¹,

Reyes-Cortes²,

Torres-Grimaldo³

et al. 2018

Epidemiol. Infect.

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Human papillomavirus (HPV) is a DNA virus linked to mucosal and cutaneous carcinogenesis. More than 200 different HPV types exist. We carried out a transversal study to investigate the prevalence of HPV types in two regions of Mexico. A total of 724 genital and non-genital samples from women (F) and men (M) were studied; 241 (33%) from North-Eastern (NE) and 483 (66%) from South-Central (SC) Mexico. The overall prevalence was 87%. In genital lesions from females, the NE group showed a prevalence of HPV types 16 (37%), 6 (13%), 59 (6%), 11, 18 and 66 (5.4% each); and the SC group showed types 6 (17%), 16 (15%), 11 (14.5%), 18 (12%) and 53 (6%). In the genital lesions from males, NE group showed types 16 (38%), 6 (21%), 11 (13%) and 59 plus 31 (7.5%) and the SC group showed types 6 (25%), 11 (22%), 18 (17%) and 16 (11.5%). When the two regions were compared, a higher prevalence of low-risk HPV 6 and 11 was found in the SC region and of high-risk HPV 59, 31 and 66 (the latter can also be present in benign lesions) in the NE region. Our findings complement efforts to understand HPV demographics as a prerequisite to guide and assess the impact of preventive interventions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus types in North and Central regions of Mexico

Luna-Aguirre¹,

Reyes-Cortes²,

Torres-Grimaldo³

et al. 2018

Epidemiol. Infect.

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“…Atualmente, a IARC (Agência Internacional para Pesquisa de Câncer) divide os HPVs em de baixo risco oncogênico (HPV-6, 11, 40, 42, 43, 44, 54, 61, 70, 72 e 81) e de alto risco oncogênico (HPV- 16,18,31,33,35,39,45,51,52,56,58,59,68, 73 e 82) de acordo com a sua capacidade de gerar neoplasias malignas (14) . Os tipos HPV- 26,53,66,67,68,70, 73 e 82 são classificados como genótipos de provável alto risco (14,31,32) .…”

Section: Epidemiologia Do Hpvunclassified

“…Sabendo-se que toda doença infecciosa e suas manifestações clínicas são resultado de interações entre agente e hospedeiro, os sintomas atípicos como os descritos acima podem ser o resultado de vários fatores intrínsecos do vírus, como isolados de HPV com atividade biológica anormal, associados a características dependentes do hospedeiro, como estado imunológico. Estudos comparativos de seqüenciamento completo do vírus presente em infecções atípicas e comuns podem ajudar a elucidar essas manifestações raras (39) .…”

Section: Epidemiologia Do Hpvunclassified

Detecção de DNA de HPV no plasma para potencial identificação precoce de recidiva de câncer do colo de útero

Centrone¹

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Aos meus pais, Antonio e Ana, por todo amor, carinho, educação dada e dedicação, por apoiarem sempre as minhas decisões e por acreditarem sempre na minha vitória. Amo vocês! Às minhas irmãs, Priscila e Larissa, pela amizade, compreensão e apoio. Aos meus tios, tio Zézão e tia Maria Ana, pelo amor que têm por mim e primos, Dani, Tati e Ari. Aos amigos que estiveram presentes em cada desafio e em cada sucesso. Dedico, em especial, a todas as pacientes que contribuíram para que esse estudo fosse possível. AGRADECIMENTOS Em primeiro lugar, agradeço a Deus por todas as bênçãos presentes na minha vida e pela família maravilhosa que tenho e que SEMPRE me apoia e acredita nos meus sonhos. Ao Dr. José Eduardo Levi, meu orientador e professor, por acreditar em mim e me dar a oportunidade de realizar este trabalho tão importante e de colaborar em outros projetos, pela sua atenção, orientação, ensino, disponibilidade e por servir de exemplo como pesquisador dedicado nos incentivando a buscar o conhecimento e nos aprimorarmos profissionalmente. Ao Prof. Dr. Cláudio Sergio Pannuti, por me receber carinhosamente neste laboratório, pela confiança e por aceitar ser meu orientador de iniciação científica para conclusão da graduação. Admiro seu exemplo de dedicação à pesquisa.

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HPV Vaccination: Prevention of Cervical Cancer in Serbia and in Europe

Stark¹,

Živković²

2018

Acta Facultatis Medicae Naissensis

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Summary The identification of the high-risk human papilloma viruses (HPVs) as a cause of cervical cancer offered the possibility for the development of a HPV vaccine. Twenty years after this identification of the HPV types, the first HPV vaccine came to the market. There are three HPV vaccines today on the market, all containing the virus-like particles (VLPs) of the HPV types 16 and 18, which are considered to cause 77 % of all cancers caused by HPVs. In addition, two of the vaccines contain two low-risk HPV types (6 and 11)-quadrivalent or the same as low-risk types and additional high-risk HPV types (31, 32, 45, 52, 58)-nonavalent vaccines. The cervical cancer protection efficacy of the vaccines is very high, around 100%. The VLPs of the 6- and 11-type offer efficient protection against genital warts. Unfortunately, the implementation of the vaccination is actually not so high despite all scientific and medical facts, but their rates in Europe are steadily increasing reaching about 90% in one country after another. In Serbia, all of the three vaccines are on the market but are highly underused. Actually, there is no national program and the Serbian vaccination rates are very low. High vaccination rates in Serbia need to be achieved as a goal of prevention of cervical cancer.

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Low and High-Oncogenic Risk Human Papillomaviruses: Every Rule Has its Exception

Cited by 4 publications

References 29 publications

Prevalence of human papillomavirus types in North and Central regions of Mexico

Prevalence of human papillomavirus types in North and Central regions of Mexico

Detecção de DNA de HPV no plasma para potencial identificação precoce de recidiva de câncer do colo de útero

HPV Vaccination: Prevention of Cervical Cancer in Serbia and in Europe

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