Low- and high-resolution nuclear magnetic resonance (NMR) characterisation of hyaluronan-based native and sulfated hydrogels

Barbucci, Rolando; Leone, Gemma; Chiumiento, A.; Cocco, Maria Enrica Di; D’Orazio, Giovanni; Gianferri, Raffaella; Delfini, Maurizio

doi:10.1016/j.carres.2006.04.046

Cited by 30 publications

(25 citation statements)

References 44 publications

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“…For example, Ghi et al [22] studied the architecture of PHEMA hydrogels, Barbucci et al [23] considered hyaluronan-based hydrogels, Hietalahti et al [24] investigated the crosslinking in unsaturated polyester solutions, Brand et al [25] focussed on the gel point determination of gelatin, Dobies et al [26] explored the gelation process of aqueous low methoxyl pectin solutions, while Abrami et al [27] delved the properties of an interpenetrated network made of alginate and Pluronic F127.…”

Section: Introductionmentioning

confidence: 99%

Use of low-field NMR for the characterization of gels and biological tissues

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Use of low-field NMR for the characterization of gels and biological tissues

et al. 2018

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“…For example, the hydrophilicity of the poly(HEMA‐ co ‐VP) polymer is higher than the one of poly(2‐hydroxyethyl methacrylate) caused by more interactions of water molecules with hydroxyl groups in poly(HEMA‐ co ‐VP) ( Ng and Swami , ). This observation is in agreement with 1 H‐NMR measurements of hyaluronan‐based native and sulfatedhydrogels ( Barbucci et al, ). The type of interaction between polymer chains and water molecules further influences the measured relaxation time, i.e ., methyl‐ester groups in HMP restrict the mobility of water molecules due to a surrounding formation of water clathrate ( Walkinshaw and Arnott , ) but not to the extent of dipolar or hydrogen‐bonded groups such as in LMP ( Kerr and Wicker , ).…”

Section: Entrapment Of Water In Hydrogelsmentioning

confidence: 99%

Biohydrogel induced soil–water interactions: how to untangle the gel effect? A review

Brax

Buchmann

Schaumann

2017

J. Plant Nutr. Soil Sci.

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Biohydrogels such as microbial exudates and root‐derived mucilage are soil‐born cross‐linked polymers, able to form porous three‐dimensional networks during water uptake. The gel effect is the variation of soil properties, such as soil hydrology and soil structural stability, resulting from biohydrogel swelling in soil. Conventionally, soil–water–hydrogel interactions are investigated by measuring soil bulk properties such as water retention curves and porosity, without further analyzing the effect of biohydrogel phases in soil on a quantitative basis. Therefore, the evaluation of advanced and novel methods for the characterization of biohydrogel phases in soil and soil–water–hydrogel interactions is necessary. This review evaluates currently available methods for their potential to analyze processes associated to the gel effect. A promising approach to investigate the spatio‐temporal distribution of biohydrogel phases in porous media is based on Nuclear Magnetic Resonance (NMR) such as 1H‐NMR relaxometry, as well as on imaging techniques such as Environmental Scanning Electron Microscopy (ESEM). Especially NMR techniques enable the identification of different water populations based on their differences in the relaxation, and thus the mobility of water molecules in biohydrogels and non‐gel water in soil pores. Rheology measures the flow behavior of biohydrogels, providing information on the structural behavior of the hydrogel network and its gelling mechanism. Soil rheology further quantifies the effect of the biohydrogel phases on the interactions between soil particles, and thus the impact on soil microstructural stability. However, rheology does not elucidate the spatio‐temporal distribution and structural state of biohydrogel phases in soil. All in all, a systematic combination of rheology, NMR and suitable imaging methods seems promising and necessary in order to elucidate the still widely unknown gel effect in soil.

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“…The cross-linking reaction occurred when hydroxyl groups in the PVA and aldehyde groups in the GA underwent an acid-catalyzed acetalization process, producing acetal and hemiacetal bridges between polymer chains. This process is stochastic in nature and has already been shown to depend on factors such as polymer concentration and reactive group tacticity [15,29,30] . A reaction scheme is shown in Figure 1.…”

Section: Sample Analysismentioning

confidence: 99%

“…When polymeric gels are not filled with fluids, they are dubbed xerogels [14] . This class of polymeric material has many applications, such as in tissue engineering, drug delivery, prosthetics and membranes applied in separation processes [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

“…Various efforts have been made to characterize polymeric gels through TD-NMR [15,[17][18][19][20][21][22] , but the majority of the reported methods involve soaking the sample in a solvent [14,19,23,24] , with the analysis being conducted under strict temperature conditions [18,20,21] , or limiting the chemical nature of the polymeric matrix to elastomers [6,12,[18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

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Time domain NMR evaluation of poly(vinyl alcohol) xerogels

2016

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SbstractPoly(vinyl alcohol) (PVA)-based chemically cross-linked xerogels, both neat and loaded with nanoparticulate hydrophilic silica (SiO 2 ), were obtained and characterized mainly through time domain NMR experiments (TD-NMR). Fourier-transform infrared (FT-IR) and wide angle X-ray diffraction (WAXD) analyses were employed as secondary methods. TD-NMR, through the interpretation of the spin-lattice relaxation constant values and related information, showed both cross-linking and nanoparticle influences on PVA matrix. SiO 2 does not interact chemically with the PVA chains, but has effect on its molecular mobility, as investigated via TD-NMR. Apparent energy of activation, spin-lattice time constant and size of spin domains in the sample have almost linear dependence with the degree of cross-linking of the PVA and are affected by the addition of SiO 2 . These three parameters were derived from a single set of TD-NMR experiments, which demonstrates the versatility of the technique for characterization of inorganic-organic hybrid xerogels, an important class of materials.

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Low- and high-resolution nuclear magnetic resonance (NMR) characterisation of hyaluronan-based native and sulfated hydrogels

Cited by 30 publications

References 44 publications

Use of low-field NMR for the characterization of gels and biological tissues

Use of low-field NMR for the characterization of gels and biological tissues

Biohydrogel induced soil–water interactions: how to untangle the gel effect? A review

Time domain NMR evaluation of poly(vinyl alcohol) xerogels

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