Low body mass index can be associated with the risk and poor outcomes of neuromyelitis optica with aquaporin-4 immunoglobulin G in women

Baek, Seol-Hee; Kim, Ji Sun; Jang, Mijung; Kim, Yoo Hwan; Kwon, Ohyun; Oh, Jung Hwan; Kang, Sa Yoon; Kang, Ji Hoon; Park, Kee Hong; Park, Yong Shik; Park, Kyung Seok; Shin, Dong Wook; Kim, Byung Jo; Kim, Sung Min

doi:10.1136/jnnp-2017-317202

Cited by 13 publications

(15 citation statements)

References 5 publications

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“…The current study also did not find an association between BMI or BF% and ARR and EDSS in NMOSD. A recent study has showed that low BMI could be associated with the risk and poor outcomes of NMOSD in women (Baek et al, ). The prospective and longitudinal data are needed to further assess this association.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that higher BMI might be associated with an increased risk of MS, comorbid conditions, and disability progression (Hedstrom, Olsson, & Alfredsson, ; Marck, Neate, Taylor, Weiland, & Jelinek, ; Marrie, ; Munger, Chitnis, & Ascherio, ). Recently, a study has showed that low BMI could be associated with the risk and poor outcomes of NMOSD in women (Baek et al, ). However, it is still unknown about the clinical implication of BF% based on CUN‐BAE in NMOSD.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a study has showed that low BMI could be associated with the risk and poor outcomes of NMOSD in women (Baek et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Blood pressure and body fat percent in women with NMOSD

et al. 2019

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Background Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra‐Body Adiposity Estimator (CUN‐BAE) in NMOSD has not been investigated thus far. Methods Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age‐ and sex‐matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined. Results Comparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110–12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = −0.522, p = 0.004). Conclusions Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood pressure and body fat percent in women with NMOSD

et al. 2019

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“…In observational studies, several risk factors are prognostic of disease outcomes in neuromyelitis optica spectrum disorder (NMOSD). Dietary or lifestyle factors associated with weight, [1][2][3][4] delayed treatment from initial diagnosis or diagnostic delay, 5,6 higher levels of disability or attack rates early in the disease course, 1,7 and being of non-White ethnicity [8][9][10][11][12][13] were linked to disease outcomes. N-MOmentum is a prospective, randomized, placebocontrolled, double-masked trial of inebilizumab, an anti-CD19 monoclonal B-cell-depleting antibody, in patients with NMOSD.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD

et al. 2021

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Background: In the N-MOmentum trial, the risk of an adjudicated neuromyelitis optica spectrum disorder (NMOSD) attack was significantly reduced with inebilizumab compared with placebo. Objective: To demonstrate the robustness of this finding, using pre-specified sensitivity and subgroup analyses. Methods: N-MOmentum is a prospective, randomized, placebo-controlled, double-masked trial of inebilizumab, an anti-CD19 monoclonal B-cell-depleting antibody, in patients with NMOSD. Pre-planned and post hoc analyses were performed to evaluate the primary endpoint across a range of attack definitions and demographic groups, as well as key secondary endpoints. Results: In the N-MOmentum trial (ClinicalTrials.gov: NCT02200770), 174 participants received inebilizumab and 56 received placebo. Attack risk for inebilizumab versus placebo was consistently and significantly reduced, regardless of attack definition, type of attack, baseline disability, ethnicity, treatment history, or disease course (all with hazard ratios < 0.4 favoring inebilizumab, p < 0.05). Analyses of secondary endpoints showed similar trends. Conclusion: N-MOmentum demonstrated that inebilizumab provides a robust reduction in the risk of NMOSD attacks regardless of attack evaluation method, attack type, patient demographics, or previous therapy. The N-MOmentum study is registered at ClinicalTrials.gov: NCT2200770.

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“…Environmental risk factors of NMOSD are still poorly identified. Few recent studies have suggested some potential risk factors for NMOSD as follows: a history of previous intentional abortion and low body mass index (BMI) only in females and head trauma and low level of physical activity in both genders (Baek et al, 2018;Rezaeimanesh et al, 2018a). Some dietary factors including low intakes of dairy, seafood, eggs, red meat, poultry, fat, fruits and vegetables over the adolescence, high-carbohydrate diet score, high carbohydrateto-protein ratio and high consumption of dietary sugars were also reported as dietary risk factors of NMOSD (Rezaeimanesh et al, 2018a(Rezaeimanesh et al, , 2018c(Rezaeimanesh et al, , 2018b.…”

Section: Introductionmentioning

confidence: 99%

Dietary total antioxidant capacity and neuromyelitis optica spectrum disorder susceptibility

Rezaeimanesh

Jahromi

Moghadasi

et al. 2019

NFS

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Purpose Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare disease with unknown risk factors. The role of oxidative stress and nutritional factors is imprecise in NMOSD development. Therefore, this paper aims to evaluate the effects of dietary total antioxidant capacity (TAC) on the odds of NMOSD. Design/methodology/approach Dietary TAC was determined in 70 definite NMOSD cases and 164 healthy controls in term of Ferric Reducing Antioxidant Power (FRAP) method. A validated 168-item semi-quantitative food frequency questionnaire (FFQ) was used for dietary assessment. Three multivariate regression models were applied to analyze the odds of NMOSD across the TAC quartiles. Findings A significant inverse association was found between dietary TAC and odds of being assigned to the NMOSD group in all three regression models. In the fully adjusted model ORs (95% CI) in the second, third and fourth quartiles of TAC vs the first quartile were as follows: 0.11 (0.04-0.29), 0.05 (0.01-0.16) and 0.01 (0.00-0.05), respectively. Odds of NMOSD also indicated a significant decreasing trend across the quartiles of dietary TAC (p-trend: <0.01). Total energy (p < 0.01) as well as consumption of vegetables (p < 0.01), whole grains (p < 0.01), tea and coffee (p < 0.01), legumes (p < 0.01) and poultry (p < 0.01) significantly increased through the TAC quartiles. Originality/value In the present study, a new hypothesis was proposed concerning the influence of dietary TAC on the odds of NMOSD. A diet rich in foods with high TAC can be effective in the modification of the NMOSD odds.

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Low body mass index can be associated with the risk and poor outcomes of neuromyelitis optica with aquaporin-4 immunoglobulin G in women

Cited by 13 publications

References 5 publications

Blood pressure and body fat percent in women with NMOSD

Blood pressure and body fat percent in women with NMOSD

Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD

Dietary total antioxidant capacity and neuromyelitis optica spectrum disorder susceptibility

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