Low body temperature and mortality in critically ill patients with coronary heart disease: a retrospective analysis from MIMIC-IV database

Abstract

Background This study was aimed to investigate the correlation between low body temperature and outcomes in critically ill patients with coronary heart disease (CHD). Methods Participants from the Medical Information Mart for Intensive Care (MIMIC)-IV were divided into three groups (≤ 36.5 ℃, 36.6–37.4 ℃, ≥ 37.5 ℃) in accordance with body temperature measured orally in ICU. In-hospital, 28-day and 90-day mortality were the major outcomes. Multivariable Cox regression, decision curve analysis (DCA), restricted cubic splines (RCS), Kaplan–Meier curves (with or without propensity score matching), and subgroup analyses were used to investigate the association between body temperature and outcomes. Results A total of 8577 patients (65% men) were included. The in-hospital, 28-day, 90-day, and 1-year overall mortality rate were 10.9%, 16.7%, 21.5%, and 30.4%, respectively. Multivariable Cox proportional hazards regression analyses indicated that patients with hypothermia compared to the patients with normothermia were at higher risk of in-hospital [adjusted hazard ratios (HR) 1.23, 95% confidence interval (CI) 1.01–1.49], 28-day (1.38, 1.19–1.61), and 90-day (1.36, 1.19–1.56) overall mortality. For every 1 ℃ decrease in body temperature, adjusted survival rates were likely to eliminate 14.6% during the 1-year follow-up. The DCA suggested the applicability of the model 3 in clinical practice and the RCS revealed a consistent higher mortality in hypothermia group. Conclusions Low body temperature was associated with increased mortality in critically ill patients with coronary heart disease.

Application of early warning system (EWS) in patients with cardiovascular disorders : a descriptive study

“…Suhu tubuh manusia normal berada diantara 36 -37,5C. Penanganan gangguan kardiovaskuler bisa dilakukan selama pasien tidak ada keluhan badan panas atau febris tidak ada penyakit infeksi yang menyertainya, tidak ada keluhan menggigil atau kedinginan dan suhu tubuh tidak kurang dari 34C [23].…”

Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database

“…Currently, the global burden of coronary artery disease (CAD) remains a critical global public health problem that requires attention, despite increasing improvements in preventive measures and treatment options [ 1 ]. Among critically ill patients in the intensive care unit (ICU), patients with coronary artery disease are likely to require treatment in the ICU after cardiac surgery, which is one of the main reasons for admission to the ICU; moreover, the mortality rate due to exacerbation of chronic cardiovascular disease within 1 year is 16.1%, which is the second leading cause of death after malignant tumours [ 2 , 3 ]. Prognostic management of patients with critical coronary artery disease is a current medical priority that requires attention; however, few current studies have evaluated the prognosis of patients with critical coronary artery disease.…”