2007
DOI: 10.1161/atvbaha.107.146860
|View full text |Cite
|
Sign up to set email alerts
|

Low C1-Inhibitor Levels Predict Early Restenosis After Eversion Carotid Endarterectomy

Abstract: Objective-Homozygotes for the normal (A) allele of mannose-binding lectin (MBL2) gene have higher risks to develop an early restenosis after eversion carotid endarterectomy (CEA). Activation of the lectin pathway is regulated by C1-inhibitor (C1-INH). The objective of the present study was to determine the predictive value of C1-INH in restenosis after CEA. Methods and Results-C1-INH and MBL-associated serine protease-2 (MASP-2) were determined in samples serially taken from 64 patients with CEA, who were foll… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
4
0

Year Published

2008
2008
2021
2021

Publication Types

Select...
5
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 9 publications
(5 citation statements)
references
References 36 publications
1
4
0
Order By: Relevance
“…However, in our earlier work, we had similar findings; for example, while C1-INH levels were predicted, CRP levels did not predict inflammation-associated restenosis of the carotid artery after eversion endarterectomy (Szeplaki et al 2007). …”
Section: Discussionsupporting
confidence: 71%
See 1 more Smart Citation
“…However, in our earlier work, we had similar findings; for example, while C1-INH levels were predicted, CRP levels did not predict inflammation-associated restenosis of the carotid artery after eversion endarterectomy (Szeplaki et al 2007). …”
Section: Discussionsupporting
confidence: 71%
“…Serum concentration of the highly sensitive CRP was determined with the particleenhanced immunoturbidimetric assay (Roche Cobas Integra 4000). Serum levels of C1 inhibitor, C3, and C9 were measured by radial immunodiffusion, as described in detail previously (Biro et al 2000;Derzsy et al 2010;Szeplaki et al 2007). Serum concentration of MASP-2 was determined using the method described in Varga et al (2008).…”
Section: Laboratory Methodsmentioning
confidence: 99%
“…More interestingly, the scFv-QuVHVL or its derivative when fully humanized may become a useful therapeutic tool, especially when used together with exogenously supplied recombinant C1-inhibitor (Padilla et al, 2007;Széplaki et al, 2007) and C4b-and C3b-scavenging (nonspecific) intravenous immunoglobulin preparations (Boackle et al,. 2006;Arumugam et al 2007), designed to control complement-mediated assaults on host tissues in circumstances such as organ transplants, antibody-mediated autoimmune diseases, extended cardiac damage following myocardial infarctions and neuronal cell death following stroke.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the impact of MBL2 genotype on the occurrence of early restenosis after CEA, the role of C1-inhibitor (C1-INH), known as an inhibitor of the lectin pathway, has been also studied [ 67 ]. The aim of the study was to determine whether the C1-INH levels have predictive value for restenosis after CEA.…”
Section: Clinical Features Of the Restenosismentioning
confidence: 99%