Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application

Liu, Jia Yun; Lim, Ken Choong; Li, Hao; Seck, Hon Luen; Yu, Xin; Kok, Shaw Wei; Zhang, Ying

doi:10.1117/12.2078809

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The downside of these methods is low availability, expensive equipment requirements, and the need for experienced technicians. However, there are many efforts to develop cheaper and more clinically friendly NLO equipment such as endoscopes that could make these methods more widespread and available for ECM imaging [41]. In addition, NLO methods share most of the same equipment and so can often be implemented on the same workstation and used alongside each other [10, 56].…”

Section: Cellular–scale Imagingmentioning

confidence: 99%

Imaging the Cardiac Extracellular Matrix

Pinkert

Hortensius

Ogle

et al. 2018

Advances in Experimental Medicine and Biology

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Cardiovascular disease is the global leading cause of death. One route to address this problem is using biomedical imaging to measure the molecules and structures that surround cardiac cells. This cellular microenvironment, known as the cardiac extracellular matrix, changes in composition and organization during most cardiac diseases and in response to many cardiac treatments. Measuring these changes with biomedical imaging can aid in understanding, diagnosing, and treating heart disease. This chapter supports those efforts by reviewing representative methods for imaging the cardiac extracellular matrix. It first describes the major biological targets of ECM imaging, including the primary imaging target of fibrillar collagen. Then it discusses the imaging methods, describing their current capabilities and limitations. It categorizes the imaging methods into two main categories: organ-scale noninvasive methods and cellular-scale invasive methods. Noninvasive methods can be used on patients, but only a few are clinically available, and others require further development to be used in the clinic. Invasive methods are the most established and can measure a variety of properties, but they cannot be used on live patients. Finally, the chapter concludes with a perspective on future directions and applications of biomedical imaging technologies.

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Section: Cellular–scale Imagingmentioning

confidence: 99%

Imaging the Cardiac Extracellular Matrix

Pinkert

Hortensius

Ogle

et al. 2018

Advances in Experimental Medicine and Biology

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High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

et al. 2016

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Full-field optical coherence tomography (FF-OCT) is a powerful tool for nondestructive assessment of biological tissue, i.e., for the structural examination of tissue in depth at a cellular resolution. Mostly known as a microscopy device for ex vivo analysis, FF-OCT has also been adapted to endoscopy setups since it shows good potential for in situ cancer diagnosis and biopsy guidance. Nevertheless, all the attempts to perform endoscopic FF-OCT imaging did not go beyond lab setups. We describe here, to the best of our knowledge, the first handheld FF-OCT endoscope based on a tandem interferometry assembly using incoherent illumination. A common-path passive imaging interferometer at the tip of an optical probe makes it robust and insensitive to environmental perturbations, and a low finesse Fabry-Perot processing interferometer guarantees a compact system. A good resolution (2.7 μm transverse and 6 μm axial) is maintained through the long distance, small diameter relay optics of the probe, and a good signal-to-noise ratio is achieved in a limited 100 ms acquisition time. High-resolution images and a movie of a rat brain slice have been recorded by moving the contact endoscope over the surface of the sample, allowing for tissue microscopic exploration at 20 m under the surface. These promising ex vivo results open new perspectives for in vivo imaging of biological tissue, in particular, in the field of cancer and surgical margin assessment.

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Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application

Cited by 2 publications

References 9 publications

Imaging the Cardiac Extracellular Matrix

Imaging the Cardiac Extracellular Matrix

High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

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