Low delayed bleeding and high complete closure rate of mucosal defects with the novel through-the-scope dual-action tissue clip after endoscopic resection of large nonpedunculated colorectal lesions (with video)

Mohammed, Abdul; Gonzaga, Ernesto Robalino; Hasan, Muhammad; Ahmed, Shahzad; Friedland, Shai; Bilal, Mohammad; Sharma, Neil; Jawaid, Salmaan; Othman, Mohamed O.; Khalaf, Mai M.; Hwang, Joo Ha; Viana, Artur; Singh, Sanmeet; Hayat, Maham; Cosgrove, Natalie; Jain, Deepanshu; Arain, Mustafa A.; Kadkhodayan, Kambiz; Yang, Dennis

doi:10.1016/j.gie.2023.07.025

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…It cannot be rotated so requires manipulation of the scope dials for positioning and operating the independent jaws can be difficult with endoscope looping. [10] The MANTIS is operated similarly to a standard TTSC. It may have a lower learning curve for both endoscopist and technician than alternative devices.…”

Section: Discussionmentioning

confidence: 99%

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A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses

Guardiola,

Rex,

Thompson

et al. 2024

Endosc Int Open

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Background & Aims: Endoscopic through-the-scope clips (TTSC) are used for hemostasis and closure. We documented the performance of a new TTSC with anchor prongs. Methods: We conducted a prospective case series of the new TTSC in 50 patients with an indication for endoscopic clipping at 3 hospitals in the USA and Canada. Patients were followed for 30 days after index procedure. Outcomes included defect closure and rate of serious adverse events (SAEs) related to the device or procedure. Results: Fifty patients had 56 clipping procedures. Thirty-four procedures were clipping after EMR in colon (33) or stomach (1), 16 after polypectomy, 2 for hemostasis of active bleeding, and 1 each for fistula closure, post-POEM mucosal closure, or anchoring a feeding tube. Complete defect closure was achieved in 32/33 colon EMR defects and 21/22 other defects. All clips were placed per labeled directions for use. In 41 (82.0%) patients, prophylaxis of delayed bleeding was reported as an indication for endoscopic clipping. There were 3 instances of delayed bleeding. There were no device-related SAEs. The only technical difficulty was one instance of premature clip deployment. Conclusion: A novel TTSC with anchor prongs showed success in a range of defect closures, an acceptable safety profile, and low incidence of technical difficulties. (ClinicalTrials.gov number, NCT05653843)

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Section: Discussionmentioning

confidence: 99%

“…This clip features two independent arms and is efficacious in closing large resection defects. Because it cannot be rotated, it requires manipulation of the scope dials for positioning and operating the independent jaws can be difficult with endoscope looping 10 . The MANTIS is operated similarly to a standard TTSC.…”

Section: Discussionmentioning

confidence: 99%

A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses

Guardiola,

Rex,

Thompson

et al. 2024

Endosc Int Open

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show abstract

“…42 More recently, we performed a multicenter prospective study demonstrating low delayed bleeding and high complete closure rate of mucosal defects with the DAT clip after endoscopic resection of large nonpedunculated colorectal lesions. 43 Data from this ongoing prospective registry demonstrated complete closure rate of 96% of postresection defects with a median size of 40 mm when using an average of one DAT and two conventional TTS clips. Delayed bleeding based on 30day follow-up was encountered in only one patient (0.9%).…”

Section: Technical Considerationsmentioning

confidence: 94%

Novel devices for third‐space endoscopy procedures

Yang,

Xiao,

Draganov

2023

Digestive Endoscopy

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Third‐space endoscopy (TSE) is a subspecialty in interventional endoscopy that exploits the submucosa as a working space for the management of various gastrointestinal diseases. Over recent years, TSE has emerged as a viable alternative to surgery for the treatment of various conditions. The rapid dissemination and adoption of TSE has been largely supported by the advent of novel devices aimed to improve the efficacy and safety of these procedures. In this article, we review some of the recent developments in TSE devices and provide our initial experience with these instruments in clinical practice.

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“…has revealed a complete closure rate of 96.3% of EMR or ESD defects with a median size of 40 mm in diameter by using this clip. 49 …”

Section: Introductionmentioning

confidence: 99%

Colorectal endoscopic submucosal dissection in the USA: The current state and future perspectives

Qatomah,

Aihara

2024

DEN Open

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Endoscopic submucosal dissection (ESD) is a transformative advancement in the endoscopic management of superficial gastrointestinal lesions. Initially conceived for the treatment of early gastric cancer, ESD has demonstrated proficiency in achieving en‐bloc resection of superficial gastrointestinal lesions. ESD has experienced widespread acceptance in Japan and East Asia; however, its adoption in the USA remains delayed. This initial hesitancy could be attributed to procedural complexity and training demands; nonetheless, recently, ESD has been gaining popularity in the USA. This is due to the advancements in endoscopic technology, tailored training programs, and cumulative evidence regarding the efficacy and safety of ESDs. This review aimed to deliberate the historical progress, current implementation, and prospective trajectory of ESDs in the USA. With ongoing clinical research, technological integration, and educational efforts, ESD is likely to become the gold standard for managing large gastrointesitinal lesions. This progress marks an imperative step toward less invasive, more precise, and patient‐centric approaches regarding advanced therapeutic endoscopy in the USA.

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Low delayed bleeding and high complete closure rate of mucosal defects with the novel through-the-scope dual-action tissue clip after endoscopic resection of large nonpedunculated colorectal lesions (with video)

Cited by 13 publications

References 29 publications

A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses

A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses

Novel devices for third‐space endoscopy procedures

Colorectal endoscopic submucosal dissection in the USA: The current state and future perspectives

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