Low-dimensional compounds containing bioactive ligands. Part VIII: DNA interaction, antimicrobial and antitumor activities of ionic 5,7-dihalo-8-quinolinolato palladium(II) complexes with K+ and Cs+ cations

Farkasová, Veronika; Drweesh, Elsayed A.; Lüköová, Andrea; Sabolová, Danica; Radojević, Ivana D.; Čomić, Ljiljana R.; Vasić, Sava M.; Paulíková, Helena; Fečko, Stanislav; Balašková, Tatiana; Vilková, Mária; Imrich, Ján; Potočňák, Ivan

doi:10.1016/j.jinorgbio.2016.11.021

Cited by 21 publications

(1 citation statement)

References 22 publications

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“…Recently, we published several papers describing the biological activities of both transition and non-transition metal complexes with HXQ. Some of them, such as K[PdCl 2 (dClQ)], Cs[PdCl 2 (dClQ)] (HdClQ = 5,7-dichloro-8-hydroxyquinoline) [18] and [Ga(ClQ) 3 ] (HClQ = 5-chloro-8-hydroxyquinoline) [19], exhibited strong and selective cytotoxic effects against tested cancer cell lines. On the other hand, although mononuclear zinc complexes with HXQ, such as K[Zn(dClQ O)] 2 •DMF•H 2 O (HdBrQ = 5,7-dibromo-8-hydroxyquinoline), have shown significant cytotoxic activity against colon cancer HCT116 cell lines, they were not selective.…”

Section: Introductionmentioning

confidence: 99%

Low-Dimensional Compounds Containing Bioactive Ligands. Part XX: Crystal Structures, Cytotoxic, Antimicrobial Activities and DNA/BSA Binding of Oligonuclear Zinc Complexes with Halogen Derivatives of 8-Hydroxyquinoline

et al. 2023

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Two tetranuclear [Zn4Cl2(ClQ)6]·2DMF (1) and [Zn4Cl2(ClQ)6(H2O)2]·4DMF (2), as well as three dinuclear [Zn2(ClQ)3(HClQ)3]I3 (3), [Zn2(dClQ)2(H2O)6(SO4)] (4) and [Zn2(dBrQ)2(H2O)6(SO4)] (5), complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ = 5,7-dichloro-8-hydroxyquinoline and HdBrQ = 5,7-dibromo-8-hydroxyquinoline) were prepared as possible anticancer or antimicrobial agents and characterized by IR spectroscopy, elemental analysis and single crystal X-ray structure analysis. The stability of the complexes in solution was verified by NMR spectroscopy. Antiproliferative activity and selectivity of the prepared complexes were studied using in vitro MTT assay against the HeLa, A549, MCF-7, MDA-MB-231, HCT116 and Caco-2 cancer cell lines and on the Cos-7 non-cancerous cell line. The most sensitive to the tested complexes was Caco-2 cell line. Among the tested complexes, complex 3 showed the highest cytotoxicity against all cell lines. Unfortunately, all complexes showed only poor selectivity to normal cells, except for complex 5, which showed a certain level of selectivity. Antibacterial potential was observed for complex 5 only. Moreover, the DNA/BSA binding potential of complexes 1–3 was investigated by UV-vis and fluorescence spectroscopic methods.

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Section: Introductionmentioning

confidence: 99%

Low-Dimensional Compounds Containing Bioactive Ligands. Part XX: Crystal Structures, Cytotoxic, Antimicrobial Activities and DNA/BSA Binding of Oligonuclear Zinc Complexes with Halogen Derivatives of 8-Hydroxyquinoline

et al. 2023

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Synthesis, characterization, cytotoxicity and computational studies of new phosphine‐ and carbodithioate‐based palladium(II) complexes

Nawaz

Waseem

Rehman

et al. 2017

Applied Organom Chemis

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In quest of new metallo‐pharmaceuticals with enhanced anticancer activity, four new phosphine‐ and carbodithioate‐based Pd(II) complexes of the type [(R)CS2Pd(PR3)Cl] (where R = 4‐(2‐hydroxyethyl)piperazine (1, 2), dibenzyl (3, 4); PR3 = diphenyl(p‐tolyl)phosphine (1, 3), tris(4‐tolyl)phosphine (2, 4)) were synthesized and characterized using elemental analysis, Fourier transform infrared and NMR (1H, 13C and 31P) spectroscopies and single‐crystal X‐ray diffraction. The X‐ray diffraction data confirmed the pseudo square‐planar geometry ensuring bidentate coordination mode of carbodithioate ligands. Anticancer activity of the synthesized complexes and their ligands was assessed against human lung (A549), breast (MCF‐7) and prostate (PC3) carcinoma cells using MTT assay. All the tested compounds showed activity in micromolar range. In many cases, the cytotoxicity of the synthesized complexes was higher than or comparable to that of the standard drugs cisplatin and doxorubicin. Complex 3 emerged as the most promising compound with the lowest IC50 values of 4.83, 3.72 and 5.11 μM for A549, MCF‐7 and PC3 carcinoma cell lines, respectively. DNA binding studies were also carried out using UV–visible spectroscopy. We extended our investigations to explore the mechanism of anticancer activity using in silico tools. Based on the mechanism of action of standard drugs used, extensive docking studies were carried out on the three different biomolecular targets.

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Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

et al. 2017

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Low-dimensional compounds containing bioactive ligands. Part VIII: DNA interaction, antimicrobial and antitumor activities of ionic 5,7-dihalo-8-quinolinolato palladium(II) complexes with K+ and Cs+ cations

Cited by 21 publications

References 22 publications

Low-Dimensional Compounds Containing Bioactive Ligands. Part XX: Crystal Structures, Cytotoxic, Antimicrobial Activities and DNA/BSA Binding of Oligonuclear Zinc Complexes with Halogen Derivatives of 8-Hydroxyquinoline

Low-Dimensional Compounds Containing Bioactive Ligands. Part XX: Crystal Structures, Cytotoxic, Antimicrobial Activities and DNA/BSA Binding of Oligonuclear Zinc Complexes with Halogen Derivatives of 8-Hydroxyquinoline

Synthesis, characterization, cytotoxicity and computational studies of new phosphine‐ and carbodithioate‐based palladium(II) complexes

Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

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