Low-dose aspirin therapy for the prevention of preeclampsia: time to reconsider our recommendations?

Horgan, Rebecca; Diab, Yara Hage; Waller, Jerri A.; Abuhamad, Alfred; Saade, George R.

doi:10.1016/j.ajog.2023.04.031

Cited by 8 publications

(2 citation statements)

References 56 publications

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“…Aspirin is the only preventive medication for PE strongly supported by research evidence (23). National guidelines recommend that women with high-risk factors can start taking aspirin before 16 weeks of gestation (24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

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Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and meta-analysis

Ye,

Li,

Ding

et al. 2023

Front. Cardiovasc. Med.

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BackgroundPre-eclampsia (PE) is a severe pregnancy complication. Thrombocytopenia and platelet dysfunction are common hematology disorders in PE. Previous studies considered mean platelet volume (MPV), a functional marker of platelets, as a potentially useful predictor for the diagnosis of PE.MethodsPubMed, China Biomedical Literature Database, Chinese National Knowledge Infrastructure, Embase, Wanfang, VIP, and Cochrane Library databases were searched to gather diagnostic trials evaluating the diagnosis of PE using MPV, from their inception to 13 March 2023. We also searched Google Scholar and Baidu.ResultsA total of 22 studies from 20 articles were found. The pooled diagnostic accuracy of the MPV for PE recognition was as follows: sensitivity (SEN) 0.676 [95% confidence interval (CI) (0.658–0.694)], specificity (SPE) 0.710 [95% CI (0.703–0.717)], and diagnostic odds ratio (DOR) 7.012 [95% CI (4.226–11.636)], and the SROC-AUC and Q* indices were 0.7889 and 0.7262, respectively. The pooled SEN, SPE, and DOR of the diagnostic accuracy of MPV for PE before 16 weeks of gestation were 0.707 [95% CI (0.670–0.743)], 0.639 [95% CI (0.611–0.667)], and 4.026 [95% CI (2.727–5.943)], and the SROC-AUC and Q* indices were 0.7278 and 0.6753, respectively. For the interval of truncation values between 9 and 10 fl, the SROC-AUC and Q* indices for MPV were 0.8856 and 0.8162, respectively.ConclusionsAvailable evidence suggests that MPV has a moderate predictive and diagnostic value for PE, particularly in diagnosing after 20 weeks of gestation. The diagnostic accuracy is higher when the MPV cut-off falls between 9 and 10 fl. The sensitivity of MPV alone in diagnosing PE is not high, and the combination of other markers for predictive diagnosis may better differentiate PE.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425154, identifier: CRD42023425154.

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Section: Introductionmentioning

confidence: 99%

“…Aspirin operates by regulating vascular homeostasis and platelet function (26). Therefore, understanding the variation in MPV and its associated predictive value in PE is increasingly crucial.…”

Section: Introductionmentioning

confidence: 99%