Low-dose computed-tomography lung cancer screening: the first European recommendations from the European Society of Radiology and European Respiratory Society

Immunoexpression analysis of selected JAK/STAT pathway molecules in non-small cell lung cancer patients

“…We looked for JAK/STAT pathway molecules whose modified immunoexpression could have diagnostic or prognostic value in lung cancer and would support clinicians in their daily practice. 23,24 Our results confirmed the increased levels of STATs, namely pSTAT3, pSTAT5, and pSTAT6, in NSCLC specimens and suggested their importance in lung carcinogenesis. The simultaneous overexpression of proteins was observed in nearly 70% of tumor samples and was similarly high, regardless of the NSCLC histotype (SCC or NSCC).…”

Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results

“…On the other hand, this may be attributable to the singlecenter design, reaching only participants in an urban area around Zurich. Within the cohort, 73% of the participants were resident in the Zurich Canton which extends for 1729 km 2 , and the median distance travelled by each participant was 16.7 km, most of which was by public transport. These data are extremely important to verify the applicability of a future structured program in our country and to provide information on centralized vs. decentralized design.…”

“…In Europe, it ranks third among the most common cancers and has the highest cancer-related death rate [ 1 ]. In Switzerland, 4500 persons are diagnosed annually with lung cancer, which is the most frequent cause of cancer-related deaths with 3200 deaths [ 2 ]. A large share of this burden would be preventable through smoking cessation or early detection of suspicious lung nodules [ 3 ].…”