Abstract:Background:No studies evaluated the role of F8 mutations in outcomes for low-dose immune tolerance induction (ITI) in people with severe hemophilia A (SHA) with hightiter inhibitors.
Objectives:To explore the association between F8 mutation types and low-dose ITI outcomes in children with SHA with high-titer inhibitors.
Methods:Children SHA with high-titer inhibitors who received low-dose ITI therapy at least for 1 year were included in this study. Based on the risk of inhibitor development, F8 mutations were … Show more
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