Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series

Hailey–Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the ATP2C1 gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients’ quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey–Hailey disease has been reported with the former in case series, while others have shown variable results. Oral magnesium chloride has been reported in four patients with possible results after 2–4 weeks. Two recent cases suggest that the combination of both treatments may have a synergistic effect. Herein, we present a 63-year-old woman with long-standing and recurrent bilateral inguinal Hailey–Hailey disease who significantly improved with low-dose naltrexone and oral magnesium chloride, representing the third case described with this combination.

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“…The treatment is mostly well tolerated with nausea, dizziness and vivid dreams (only one episode) reported seldomly. 9,14…”

Section: Discussionmentioning

confidence: 99%

Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

Lim

Bélisle

Davar

2020

SAGE Open Medical Case Reports

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“…To date, several case studies have been published showing improvement with LDN in the treatment of HHD . However, a recent large case series showed varying responses to LDN . The eight cases presented here help to explore further the usefulness of this therapy by showing a beneficial effect on both skin symptoms and QoL.…”

Section: Patient Characteristics and Response To Treatmentmentioning

confidence: 99%

Improvement of Hailey–Hailey disease with low‐dose naltrexone

et al. 2020

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“…One interesting observation we made in the article was the response of one patient to the standard higher dose (50 mg) of naltrexone. Two previous studies that used the 50‐mg dose in patients with HHD (three patients in total) had failed to show any positive response . However, it should be noted that in the study of Jasans‐Barceló et al .…”

mentioning

confidence: 92%

“…Two previous studies that used the 50-mg dose in patients with HHD (three patients in total) had failed to show any positive response. 2,3 However, it should be noted that in the study of Jasans-Barcel o et al the patient who showed a response to the higher dose had markedly greater body surface area involvement (20%) and was older (age 86 years). 1 In this context, we believe that it is important to re-emphasize and understand the importance of naltrexone dosing in the treatment of HHD.…”

mentioning

confidence: 96%