Low‐dose propofol to prevent nausea and vomiting after laparoscopic surgery

Fujii, Yoshitaka; Itakura, Michiyo

doi:10.1016/j.ijgo.2009.03.008

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…Small dose (0.5 mg kg -1 ) of propofol administered i.v. at the end of surgery was effective for preventing PONV in women undergoing gynecologic laparoscopic surgery [84]. By contrast, Montgomery et al found no effect of subhypnotic dose (0.1 mg kg -1 h -1 ) of propofol infusion for 24 h postoperatively in women undergoing major gynecological surgery [17].…”

Section: Propofol Dexamethasone and Ephedrinementioning

confidence: 97%

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Fujii

2011

CDTH

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Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events associated with anesthesia and surgery, with a high incidence after major gynecological surgery (e.g., abdominal hysterectomy). Numerous antiemetics have been studied for the prevention and treatment of PONV after this surgical procedure.Most of the published trials indicate the improved prevention of PONV by avoiding risk factors and/or by using antiemetic therapy in women undergoing major gynecological surgery. Pharmacological approaches include phenothiazines (e.g., perphenazine), butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., cyclizine), proppofol, dexamethasone, ephedrine, serotonin receptor antagonists (e.g., ondansetron, granisetron) and neurokinin-1 receptor antagonists (e.g., aprepitant). None of the currently available antiemetics is entirely effective, perhaps because most of them act through the blockade of one type of receptor. There is a possibility that combined antiemetics with different sites of activity would be more effective than one drug alone preventing PONV. Combination antiemetic regimens (e.g., ondansetron plus droperidol) are highly effective in the prevention of PONV. As non-pharmacological therapy, acupressure and acupuncture at the P6 (Nei-Kuwan) point are effective for preventing PONV. For the treatment of established PONV, granisetron is more effective than droperidol or metoclopramide.In the management of PONV after major gynecological surgery, the benefits and risks of these clinical strategies should be considered.

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Section: Propofol Dexamethasone and Ephedrinementioning

confidence: 97%

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Fujii

2011

CDTH

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“…However, a recent study in patients undergoing gynecological laparoscopy found that bolus doses of propofol 0.5 mg/kg administered at the end of surgery were effective in reducing PONV, when compared to placebo. [ 39 ] Lower doses than this were not effective.…”

Section: Antiemeticsmentioning

confidence: 99%

Postoperative analgesia for gynecological laparoscopy

Gibbison

Kinsella

2009

Saudi J Anaesth

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Gynecological laparoscopy is a commonly performed procedure. Providing anesthesia for this can present a challenge, particularly in the day surgery population. Poor analgesia, nausea, and vomiting can cause distress to the patient and increased cost for the health system, because of overnight admission. In this review we discuss anesthetic and analgesic techniques for day-case gynecological laparoscopy. The principles include multimodal analgesia, the use of the oral route wherever possible, and the contribution of the surgeon.

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“…Propofol은 5-HT3 수용체 차단제의 역할 [13] 또는 중추신 경계의 화학수용체 방아쇠 영역과 오심 및 구토와 관련된 미주신경 등의 직접적인 억제 작용을 통해 [14] PONV 예방 및 치료에 효과가 있다고 하나, 마취 유도제로 쓰였을 경우의 PONV 예방 효과에 대해서는 여러 가지 이견이 있다 [5,[15][16][17][18][19][20][21]. Values are number of patients.…”

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The effects of prophylactic dolasetron and induction with propofol on postoperative nausea and vomiting after thyroidectomy

Joe

Park

et al. 2009

Korean J Anesthesiol

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Background: Postoperative nausea and vomiting (PONV) is a common problem in patients undergoing thyroidectomy. In this study we evaluated the effects of prophylactic dolasetron and/or induction with propofol on PONV. Methods: Two hundred three patients scheduled thyroidectomy under general anesthesia with sevoflurane were included and were randomly allocated to one of four groups. In control (group C) and dolasetron groups (group D), the patients received thiopental sodium 4−5 mg/kg intravenously for the induction of anesthesia, and the patients in group D received prophylactic intravenous dolasetron 210 μg/kg. In propofol (group P) and dolasetron ＋ propofol groups (group D ＋ P), the patients received propofol 2 mg/kg intravenously for the induction of anesthesia, and the patients in group D ＋ P received prophylactic intravenous dolasetron 210 μg/kg. The incidence and severity of PONV, the need for rescue antiemetics, adverse events were assessed during 0 to 1 hour and 1 to 24 hours postoperatively. Results: During the first 24 hours after anesthesia, the incidences of PONV and postoperative vomiting were significantly reduced in group D ＋ P compared with group C (P ＜ 0.05, respectively). There were no significant differences in postoperative nausea, need for rescue antiemetics, severity of PONV, and adverse events of antiemetics among the four groups. Conclusions: In patients with thyroidectomy, combination of prophylactic dolasetron administration and induction with propofol was found to reduce the incidence of PONV during the first 24 hours after anesthesia, compared with that of routine induction with thiopental sodium.

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Low‐dose propofol to prevent nausea and vomiting after laparoscopic surgery

Abstract: Prophylactic therapy with 0.5 mg/kg of propofol was found to be effective in preventing nausea/vomiting in patients undergoing gynecologic laparoscopic surgery.

Cited by 11 publications

References 17 publications

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Postoperative analgesia for gynecological laparoscopy

The effects of prophylactic dolasetron and induction with propofol on postoperative nausea and vomiting after thyroidectomy

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