Low-Dose Radiation Does Not Induce Proliferation in Tumor Cells<i>In Vitro</i>and<i>In Vivo</i>

Jiang, Hongyu; Ying, Xu; Li, Wei; Ma, Kewei; Cai, Lu; Wang, Guanjun

doi:10.1667/rr1132.1

Cited by 34 publications

(33 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This information will be of great importance since exposure times and doses of LDR can be manipulated to favor anti‐cancer therapy. We have demonstrated, for the first time, that LDR‐induced proliferative effects are absent in cancer cells, including leukemia and solid tumor cells, in vitro and in vivo at the same experimental condition . Although the lack of AR induced by LDR has been observed in cancer cells, including mouse skin papilloma cells (308 cells) and X‐ray‐sensitive lymphoma cells (L5178 Y‐S and EL‐4), and Chen et al .…”

Section: Ldr Does Not Induce Hormesis and Ar In Cancer Cellsmentioning

confidence: 69%

Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

Yang

Jiang

et al. 2016

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

It has been generally accepted that both natural and man-made sources of ionizing radiation contribute to human exposure and consequently pose a possible risk to human health. However, accumulating evidence has shown that the biological effects of low-dose radiation (LDR) are different from those of high-dose radiation. LDR can stimulate proliferation of normal cells and activate their defense systems, while these biological effects are not observed in some cancer cell types. Although there is still no concordance on this matter, the fact that LDR has the potential to enhance the effects of cancer therapeutics and reduce the toxic side effects of anti-cancer therapy has garnered significant interest. Here, we provide an overview of the current knowledge regarding the experimental data detailing the different responses of normal and cancer tissues to LDR, the underlying mechanisms, and its significance in clinical application.

show abstract

Section: Ldr Does Not Induce Hormesis and Ar In Cancer Cellsmentioning

confidence: 69%

Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

Yang

Jiang

et al. 2016

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Effects of LDR are distinct from those of moderate‐ or high‐level radiation, which stimulate beneficial effects including cell proliferation, metabolic activity and anti‐inflammatory and anti‐oxidant effects . Our previous work suggests that exposure to repetitive LDR (25 mGy/day) induces anti‐inflammatory effects in the hearts at the early stage of diabetes .…”

Section: Discussionmentioning

confidence: 97%

Low‐dose radiation prevents type 1 diabetes‐induced cardiomyopathy via activation of AKT mediated anti‐apoptotic and anti‐oxidant effects

Zhang

Lin

et al. 2016

J Cellular Molecular Medi

View full text Add to dashboard Cite

We investigated whether low‐dose radiation (LDR) can prevent late‐stage diabetic cardiomyopathy and whether this protection is because of the induction of anti‐apoptotic and anti‐oxidant pathways. Streptozotocin‐induced diabetic C57BL/6J mice were treated with/without whole‐body LDR (12.5, 25, or 50 mGy) every 2 days. Twelve weeks after onset of diabetes, cardiomyopathy was diagnosed characterized by significant cardiac dysfunction, hypertrophy and histopathological abnormalities associated with increased oxidative stress and apoptosis, which was prevented by LDR (25 or 50 mGy only). Low‐dose radiation‐induced cardiac protection also associated with P53 inactivation, enhanced Nrf2 function and improved Akt activation. Next, for the mechanistic study, mouse primary cardiomyocytes were treated with high glucose (33 mmol/l) for 24 hrs and during the last 15 hrs bovine serum albumin‐conjugated palmitate (62.5 μmol/l) was added into the medium to mimic diabetes, and cells were treated with LDR (25 mGy) every 6 hrs during the whole process of HG/Pal treatment. Data show that blocking Akt/MDM2/P53 or Akt/Nrf2 pathways with small interfering RNA of akt, mdm2 and nrf2 not only prevented LDR‐induced anti‐apoptotic and anti‐oxidant effects but also prevented LDR‐induced suppression on cardiomyocyte hypertrophy and fibrosis against HG/Pal. Low‐dose radiation prevented diabetic cardiomyopathy by improving cardiac function and hypertrophic remodelling attributed to Akt/MDM2/P53‐mediated anti‐apoptotic and Akt/Nrf2‐mediated anti‐oxidant pathways simultaneously.

show abstract

“…6,33 A low dose of ionizing radiation (LDR) is of antitumor activity and enhance the effectiveness of cancer therapeutics. Enhancing normal cell proliferation is a well-documented effect of low dose of gamma radiation, but this effect is absent in cancer cells, including leukemia and solid tumor cells, in vitro and in vivo 34 which favors recovery of damaged tissues during anti-cancer therapy. Previous studies pronounced antitumor effect of LDR on pulmonary tumor metastases.…”

Section: Discussionmentioning

confidence: 99%

Phenolic Profile and In Vivo Cytotoxic Activity of Rice Straw Extract

Ibrahim¹,

Mm²,

Nh³

et al. 2019

View full text Add to dashboard Cite

Background: Previous work of our team exhibited that rice straw (RS) has antitumor activity in vitro and inhibit proliferation of liver, lung, prostate, and breast cancer human cell lines. In this work, we extended our research to screen the antitumor activity of RS ethanol extract as a single treatment and in the presence of combined radiotherapy with a low dose of gamma radiation against murine Ehrlich solid carcinoma (EAC) model. Objective: To evaluate the most common waste in Egypt RS to screen out its in vivo cytotoxic activity and as combined therapy with radiotherapy. Method: Tested sample RS was investigated for its content of phenolics by LC/MS/MS, in addition, ethanolic extracts of the tested sample were investigated as antitumor on female mice inoculated with EAC cells as a single treatment and in the presence of combined radiotherapy with a low dose of gamma radiation (LDR). Results: LC/MS/MS revealed that rice straw was rich in phenolic acids (vanillic, p-coumaric, ferulic, and sinapic acid) along with catechin and flavonoids aglycones (quercetin, apigenin, and kaempferol). Rice straw and/or exposure to a low dose of γ-radiation caused a marked suppression of tumor growth and induced significant reduction in VEGF level & in IL-6 level with significant elevation in IL-10 serum level. Rice straw caused a significant down regulation in the gene transcription level of MCL1 and b-catenin, and a significant up-regulation of Caspase-3 and Bax gene expression. RS extract and LDR (EC + RS + R group) revealed that there was a mild form of necrosis with severe apoptosis in the tumor cells. Conclusion: From the aforementioned results, it can be concluded that RS/LDR effectively and synergistically work towards inhibition of cancer cell proliferation. These findings were well supported with histopathological studies suggesting that RS/low dose gamma radiation can serve as a good therapeutic agent against cancer but still need further clinical studies.

show abstract

Low-Dose Radiation Does Not Induce Proliferation in Tumor CellsIn VitroandIn Vivo

Cited by 34 publications

References 29 publications

Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

Low‐dose radiation prevents type 1 diabetes‐induced cardiomyopathy via activation of AKT mediated anti‐apoptotic and anti‐oxidant effects

Phenolic Profile and In Vivo Cytotoxic Activity of Rice Straw Extract

Contact Info

Product

Resources

About