Low dose sublingual therapy in patients with allergic rhinitis due to house dust mite

Abstract

Summary In a double‐blind placebo‐controlled cross‐over trial, low dose sublingual therapy with house dust mite was effective in relieving symptoms in 72% of the group of patients with perennial rhinitis due to house dust mite (P < 0·03). Following active treatment, there was a significant increase in morning peak nasal inspiratory flow rate (P < 0·01) in those who improved (thirteen out of eighteen) and resistance to nasal provocation with house dust mite also increased, in some cases up to 1000‐fold (P < 0·05). Oral therapy is safe and avoids the side effects of desensitizing injections which can be serious. The potential for oral desensitization is great and further studies on this form of treatment are needed.

Allergen‐specific immunotherapy: from therapeutic vaccines to prophylactic approaches

“…To reduce side effects in the course of SIT, both Marsh et al and Lee and Sehon developed procedures for the chemical modification of allergen extracts and obtained modified allergen extracts with low allergenic activity [22,23]. In 1986, Scadding and Brostoff [24] Table 1 Overview of milestones in the development of SIT 1903 Pollen-specific anti-sera neutralize pollen-induced allergic reactions Dunbar [15] 1911 Subcutaneous injection of grass-pollen extract in allergic patients reduces allergic symptoms Noon [16] 1927 Oral administration of pollen extract for SIT Black [17] 1935 Demonstration that SIT induces an allergen-specific serum factor that inhibits allergic reactions…”

Treating allergic rhinitis by sublingual immunotherapy: a review

“…However, if the reactions are of the anaphylactic type, they may be severe and, though very rarely, even fatal [7]. In 1987, the sublingual route was proposed for AIT [8], and in the ensuing years it emerged as the best option for immunotherapy, by demonstrating a comparable efficacy and better Riassunto (Il trattamento della rinite allergica con l'immunoterapia sublinguale: revisione della letteratura). Obiettivo.…”

Quality of Life Improvement after Sublingual Immunotherapy for Allergic Rhinitis

“…AR is a chronic disease showing symptoms of nasal congestion, nasal itching, rhinorrhea and sneezing [2]Medical cost for AR treatment is increasing, and considering comorbid diseases including asthma, the treatment of AR has become more than just treating the rhinitis itself [3]. AR treatment can be classified into 4 categories: (1) avoidance and environmental control, (2) pharmacotherapy, (3) surgical treatment and (4) immunotherapy.…”

“…AR treatment can be classified into 4 categories: (1) avoidance and environmental control, (2) pharmacotherapy, (3) surgical treatment and (4) immunotherapy. Avoidance and environmental control is the safest way, but these are not always feasible.…”