Low dose wall motion score predicts the short and long-term benefit of surgical revascularization in patients with ischemic left ventricular dysfunction

Ghaffar, Yasir Abdul; Maskoun, Waddah; Mustafa, Nowwar; Feigenbaum, Harvey; Sawada, Stephen

doi:10.1007/s10554-019-01614-9

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Left ventricular cardiac reserve is an index of global inotropic function increasing during both physical exercise and pharmacological stress test (usually with dobutamine), of well-established prognostic value [4,30]. In patients with HF this parameter is used to assess the likelihood for improvement of the LVEF following treatment, whether medical, surgery [31] or device implantation [4,30]. CR has been also shown to correlate with the amount of viable myocardium post infarction [32].…”

Section: Discussionmentioning

confidence: 99%

Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study

Шипулин

Андреев

Pryakhin

et al. 2022

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Purpose: The purpose of present study was to assess the feasibility of GBPS with low-dose dobutamine (LDD) stress test, performed on a SPECT camera equipped with Cadmium-Zinc-Telluride (CZT) solid state detectors in evaluation of patients with ischemic heart failure (HF).Methods. A total of 52 patients with ischemic cardiomyopathy (ICM) and a control group of 10 patients without obstructive coronary artery lesion underwent GBPS and transthoracic echocardiography (TTE) at rest and during LDD stress test (5, 10, 15 µg/kg/min). The duration of each GBPS step was 5 minutes.Stress-induced changes (∆) in LV ejection fraction (LVEF), peak ejection rate, LV volumes and dyssynchrony (phase histogram standard deviation, phase histogram bandwidth and entropy) obtained with GBPS were estimated.Results. All GBPS indices except end-diastolic volume showed signi cant dynamics during stress test in both groups. 17% of ICM patients, but none from control group, showed a decrease in EF during stress, accompanied by a signi cant increase in entropy. The inter-rater reproducibility was excellent for both rest and stress studies. There was a moderate correlation (r=0.5, p=0.01) between GBPS and TTE, with a mean difference value of -1.7 (95% con dence interval -9.8; 6.4; p=0.06) in ΔLVEF.Conclusion. Low-dose dobutamine stress gated blood pool SPECT performed with high-e ciency CZT-SPECT cameras allow evaluation of stress-induced changes in LV contractility and dyssynchrony in patients with ischemic HF. The high sensitivity of the semiconductor detectors provides an opportunity to perform GBPS with lower acquisition time and a decrease in patient radiation exposure.ClinicalTrials.gov identi er: NCT04508608 (

show abstract

Section: Discussionmentioning

confidence: 99%

Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study

Шипулин

Андреев

Pryakhin

et al. 2022

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…On top of this study, another study was conducted by Ghaffar et al, in which they tried to determine if the extent of the viable myocardium in patients with left ventricle failure could predict short- and long-term advantages after coronary artery bypass grafting (CABG) compared with medical therapy [ 12 ]. In that study, 250 patients with ≥4 resting segment abnormalities during a rest echocardiogram with a mean EF = 32 ± 7 underwent LDDSE for an assessment of myocardial viability.…”

Section: Viability and Lddsementioning

confidence: 99%

The Utility of Low-Dose-Dobutamine Stress Echocardiography in Patients with Heart Failure with Reduced Ejection Fraction: An Update

Tsigkriki,

Kleitsioti,

Dimitriadis

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Despite significant advancements in medical therapy, heart failure with reduced ejection fraction (HFrEF) continues to be a significant cause of death and disability. Reversible ischaemic left ventricular dysfunction due to viable myocardium is one such contributing factor. In these cases, coronary revascularization has shown promise in improving left ventricular function and prognosis. For patients with HFrEF and wide QRS, cardiac resynchronization therapy (CRT) is an effective option to address electromechanical dyssynchrony. However, approximately 30% of patients do not respond positively to CRT, highlighting the need to refine candidate selection for this treatment. In some patients with reduced HFrEF, there is a condition known as classical low-flow, low-gradient aortic stenosis (AS) that may be observed. This condition is characterized by a low transaortic flow, which leads to reductions in both the transaortic mean gradient and aortic valve area. Decision-making regarding revascularization, CRT, and pharmacological treatment play a crucial role in managing HFrEF. Cardiac imaging can be valuable in guiding decision-making processes and assessing the prognosis of patients with HFrEF. Among the imaging modalities, dobutamine stress echocardiography has come a long way in establishing itself as a feasible, safe, effective, relatively cheap non-invasive technique. The aim of this review is to explore the current literature on the utility of low-dose stress echocardiography in diagnosing and prognosticating patients with HFrEF.

show abstract

Utility of coronary revascularization in patients with ischemic left ventricular dysfunction

Al-Sadawi,

Tao,

Dhaliwal

et al. 2024

Cardiovascular Revascularization Medicine

View full text Add to dashboard Cite

Low dose wall motion score predicts the short and long-term benefit of surgical revascularization in patients with ischemic left ventricular dysfunction

Cited by 4 publications

References 27 publications

Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study

Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study

The Utility of Low-Dose-Dobutamine Stress Echocardiography in Patients with Heart Failure with Reduced Ejection Fraction: An Update

Utility of coronary revascularization in patients with ischemic left ventricular dysfunction

Contact Info

Product

Resources

About