Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Abstract

The low dose of radiation (LDR) has received growing attention for its beneficial neuroprotective effect. This study was designed to investigate the enhancing effect of LDR on the antidepressant potential of resveratrol against diazepam‐induced depression in mice. Female mice divided into five groups; control, diazepam (2 mg/kg), LDR (0.5Gy) + diazepam, resveratrol (20 mg/kg) + diazepam, LDR + resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro‐histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.

Nrf2 and NF‐қB interplay in tamoxifen‐induced hepatic toxicity: A promising therapeutic approach of sildenafil and low‐dose γ radiation

“…These findings are in line with the results of 38 . All these findings were diminished by Sildenafil and low‐dose gamma irradiation 13,22 …”

“…38 All these findings were diminished by Sildenafil and low-dose gamma irradiation. 13,22 This preliminary study examined the effects of sildenafil and low-dose gamma irradiation as a novel approach against the deleterious effect of tamoxifen. Where, the overall results, suggest significant liver improvement through reduction in oxidative stress, inflammatory damage and endothelial dysfunction-induced hepatic damage owing to chemotherapy complications with tamoxifen.…”

“…Furthermore, low‐dose radiation (LDR) has been reported to trigger natural protection mainly by motivating apoptotic mechanism, immune system and various cell regulatory proteins 20,21 . Since exposure to LDR could suppress reactive oxygen species‐related disease models such as acute hepatitis, type 1 diabetes and Parkinson disease, depression 22,23 and stimulate functioning immune system 24 . Hence, LDR could be considered as one of the promising stimulating treatments for biological systems 23,25,26 …”

Neonatal exposure to low‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice

“…Irradiation with 6 Gy induces anxiety in the mouse 38 . Irradiation of PD10 mice with 0.5 Gy, induced cognitive impairment in the adulthood, 39 however, irradiation with the same dose markedly ameliorated diazepam‐induced depression in adult mice 40 . The impairment of the spatial learning and emotional regulation ability of mice induced by 2 Gy irradiation at PD3(Figures 3 and 4) may be associated with hippocampal neuroinflammation and changes in synaptic plasticity 41–44 …”

“…38 Irradiation of PD10 mice with 0.5 Gy, induced cognitive impairment in the adulthood, 39 however, irradiation with the same dose markedly ameliorated diazepam-induced depression in adult mice. 40 The impairment of the spatial learning and emotional regulation ability of mice induced…”