Low-energy electron therapy

Sanche, Léon

doi:10.1038/nmat4333

Cited by 29 publications

(24 citation statements)

References 6 publications

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“…However, this type of radiotherapy is expected to be limited to Transient Anions in Radiobiology and Radiotherapy: From Gaseous Biomolecules to Condensed Organic and Biomolecular Solids http://dx.doi.org/10.5772/63293 superficial tumors, owing to the requirement for that low-energy (<100 keV) X-rays be used to optimize LEE production and hence radiosensitization by the photoelectric effect. To treat deep tumors, a radioactive source may have to be encapsulated inside a gold nanoparticle (i.e., in a gold nanocage) [219]. Furthermore, if DNA specificity cannot be achieved in patients, successful treatment may still be possible by intratumor injection of GNPs, as recently shown by Shi et al [220] and Bobyk et al [204].…”

Section: Interaction Of Lees With Dna Bound To Gold Nanoparticlesmentioning

confidence: 99%

Transient Anions in Radiobiology and Radiotherapy: From Gaseous Biomolecules to Condensed Organic and Biomolecular Solids

Alizadeh¹,

Ptasińska²,

Sanche³

2016

Radiation Effects in Materials

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This chapter focuses on the fundamental processes that govern interactions of lowenergy (1-30 eV) electrons with biological systems. These interactions have been investigated in the gas phase and within complex arrangements in the condensed phase. They often lead to the formation of transient molecular anions (TMAs), and their decay by autoionization or dissociation accompanied by bond dissociation. The damage caused to biomolecules via TMAs is emphasized in all sections. Such damage, which depends on a large number of factors, including electron energy, molecular environment, and type of biomolecule, and its physical and chemical interactions with radiosensitizing agents are extensively discussed. A majority of recent findings resulting from experimental and theoretical endeavors are presented. They encompass broad research areas to elucidate important roles of TMAs in irradiated biological systems, from the molecular level to nanoscale cellular dimensions. Fundamental aspects of TMA formation are stressed in this chapter, but many practical applications in a variety of radiation-related fields such as radiobiology and radiotherapy are addressed.

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Section: Interaction Of Lees With Dna Bound To Gold Nanoparticlesmentioning

confidence: 99%

Transient Anions in Radiobiology and Radiotherapy: From Gaseous Biomolecules to Condensed Organic and Biomolecular Solids

Alizadeh¹,

Ptasińska²,

Sanche³

2016

Radiation Effects in Materials

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“…However, current chemotherapeutic drugs have significant side effects on normal healthy cells and tissues if administrated by traditional routes; these are commonly myelosuppression, mucositis and alopecia [3]. Therefore, the major challenge in chemotherapy is to develop drug delivery systems (DDSs) to deliver chemotherapeutic drugs safely and efficaciously without side effects.…”

Section: Introductionmentioning

confidence: 99%

An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers

et al. 2016

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The development of more effective cancer therapeutic strategies are still critically required. The maximization of the therapeutic effect in combination with avoiding the severe side effects on normal tissues when using chemotherapy drugs is still an urgent problem that requires improvements urgently. Here we provide implantable and controllable drug-release that utilises silk fibroin (SF) as a nanofibrous drug delivery system (DDS) for cancer treatment. A nanofibrous structure with controllable fibre diameter (<100 nm) was produced. The drug release rate of the SF DDS was controlled by applying a post-treatment process. In vitro anti-cancer (HCT116) results indicated that curcumin (CM)-SF nanofibrous matrix had a superior anti-cancer potential when the concentration was >5 μg/mL. The mechanism could be explained by the cell cycle being held in the S phase. The toxic effect on normal cells (NCM460) was minimized by using a treatment concentration range (5-20 μg/mL). Implantation of this DDS into the tumour site inhibited the growth of solid tumour; this offers an alternative approach for novel cancer therapy.

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“…These transitions were observed experimentally by Müller et al [15,16]. It should be noted that double and triple Auger transitions can be of the largest importance for the K shell decay in elements potentially applicable for targeted cancer therapies [17][18][19].…”

Section: Introductionmentioning

confidence: 71%

Single, double, and triple Auger processes in C$^{1+}$ for attosecond spectroscopy

Jonauskas,

Masys

2018

Preprint

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We predict that attosecond spectroscopy could be used to observe time delay for electron emission in the C 1+ ion from a few step processes that include electron impact excitation. The results reveal that the photon energy corresponding to the excitation to the 1s2s 2 2p 2 2 D 1.5 level from the ground one has to be used to study the emission of the electrons produced with the largest probability from a few step processes. Double and triple Auger processes are investigated in the C 1+ ion as a sequence of single Auger transition with subsequent ionization by the Auger electron. Single-and two-step processes describe the double Auger transition while the triple Auger transition arises from two-and three-step processes. Fairly good agreement with experimental values for cross sections demonstrates that inner shell excitation by photon leads to subsequential emission of the electrons in the double and triple Auger processes.

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Low-energy electron therapy

Cited by 29 publications

References 6 publications

Transient Anions in Radiobiology and Radiotherapy: From Gaseous Biomolecules to Condensed Organic and Biomolecular Solids

Transient Anions in Radiobiology and Radiotherapy: From Gaseous Biomolecules to Condensed Organic and Biomolecular Solids

An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers

Single, double, and triple Auger processes in C$^{1+}$ for attosecond spectroscopy

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