Low Expression Myeloperoxidase Genotype Negatively Associated with Helicobacter pylori Infection

Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles

“…This observation appears sex-specific as this association could not be observed among male subjects. It is most intriguing that these results are corresponding to the associations reported for different diseases such as lung cancer, [12][13][14] esophageal cancer, 15 coronary artery disease, 16 Helicobacter pylori infections 17 and neuro-degenerative disorders, ie Alzheimer's disease 18 and multiple sclerosis. 19 In all these studies, the allelic variant MPO −463A elicited a protective effect with nearly identical odds ratios in the range of 0.3-0.7.…”

“…In some of these studies gender-specific results were presented showing the protective effect of the MPO A-allele either only in females 18,19 or only in males. 17 There must be a common link leading to this correspondence in the different clinical settings. Inflammationrelated recruitment of neutrophil leukocytes into the affected tissue is most likely responsible for the different protective effects seen in the various studies mentioned.…”

Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

“…Concerning Helicobacter pylori infection, a well-known cause of digestive diseases including gastric cancer, polymorphism studies of the host are still limited. To date, associations of H. pylori seropositivity with HLA types [2] and polymorphisms of secretor [3], Lewis [3], interleukin 1B (IL-1B) [4][5][6][7], myeloperoxidase [8], tumor necrosis factor A (TNF-A) [9], and TCRBV6S1 [10] have been reported.…”

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection

“…13 Recent studies show MPO genotype to be associated with increased risk for a variety of inflammatory and autoimmune conditions. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] This suggests the local cellular expression of MPO may play a role in the pathogenesis of different disease states. In the present study, we investigated the relationship between the MPO promoter polymorphism and liver fibrosis in patients with chronic (HCV) hepatitis.…”