Low expression of CDK12 in gastric cancer is correlated with advanced stage and poor outcome

Liu, Meijia; Fan, Haonan; Li, Tianfu; Lu, Si-Hong; Qiao, Shan; Bi, Jiong

doi:10.1016/j.prp.2020.152962

Cited by 8 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a mutual mediation effect between K. sedentarius and the hypermethylation of the cg26279814 site of the CDK12 gene. Previous studies have shown that the expression level of CDK12 in gastric cancer was correlated with advanced stages and poor outcomes and was positively correlated with the CD8 cell density ( 46 , 47 ). The potential of CDK12 / PAK2 as a therapeutic target for patients with gastric cancer was highlighted in a previous study ( 48 ).…”

Section: Discussionmentioning

confidence: 96%

Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

et al. 2023

View full text Add to dashboard Cite

The burgeoning field of oncobiome research declared that members of the intratumoral microbiome besides Helicobacter pylori existed in tumor tissues and participated in the occurrence and development of gastric cancer, and the methylation of host DNA may be a potential target of microbes and their metabolites. Current research focuses mostly on species composition, but the functional genes of the members of the microbiota are also key to their interaction with the host.

show abstract

Section: Discussionmentioning

confidence: 96%

Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

et al. 2023

View full text Add to dashboard Cite

show abstract

“…CDK12 expression is high in some cancers and lower in some cancers, and in the case of gastric cancer, it has been observed to be downregulated, and is negatively correlated with poor outcomes, poorly differentiated adenocarcinoma, and advanced stage; therefore CDK12, could be a tumor suppressor in gastric cancer [233]. The CDK12 gene has been reported to be one of the driver genes that regulates the growth of gastric cancer.…”

Section: Other Cdks In Gastric Cancermentioning

confidence: 99%

The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer

Javed

Yarmohammadi

Korkmaz

et al. 2023

IJMS

View full text Add to dashboard Cite

Gastric cancer predominantly occurs in adenocarcinoma form and is characterized by uncontrolled growth and metastases of gastric epithelial cells. The growth of gastric cells is regulated by the action of several major cell cycle regulators including Cyclins and Cyclin-dependent kinases (CDKs), which act sequentially to modulate the life cycle of a living cell. It has been reported that inadequate or over-activity of these molecules leads to disturbances in cell cycle dynamics, which consequently results in gastric cancer development. Manny studies have reported the key roles of Cyclins and CDKs in the development and progression of the disease in either in vitro cell culture studies or in vivo models. We aimed to compile the evidence of molecules acting as regulators of both Cyclins and CDKs, i.e., upstream regulators either activating or inhibiting Cyclins and CDKs. The review entails an introduction to gastric cancer, along with an overview of the involvement of cell cycle regulation and focused on the regulation of various Cyclins and CDKs in gastric cancer. It can act as an extensive resource for developing new hypotheses for future studies.

show abstract

“…Mutations in HR genes, particularly BRCA1, PALB2, and RAD51C, which are important to maintain genome integrity in response to DNA damage, have been shown to increase GC risk [19,148]. CDK12 participates in DNA repair and contributes to cell division fidelity and genomic stability after DNA damage; its mutation has been reported in several malignancies, and decreased CDK12 expression is associated with a worse prognosis in GC [149]. Various other genes are recurrently altered in GC, albeit at a low frequency, including some coding for proteins involved in the regulation of the MRN complex, which recognizes DNA damage and triggers DDR [23,150].…”

Section: Hr: the Predominant Dsb Repair Pathwaymentioning

confidence: 99%

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities

De Marco,

Sanese,

Simone

et al. 2023

Cancers

View full text Add to dashboard Cite

Gastric cancer (GC), one of the most common malignancies worldwide, is a heterogeneous disease developing from the accumulation of genetic and epigenetic changes. One of the most critical epigenetic alterations in GC is DNA and histone methylation, which affects multiple processes in the cell nucleus, including gene expression and DNA damage repair (DDR). Indeed, the aberrant expression of histone methyltransferases and demethylases influences chromatin accessibility to the DNA repair machinery; moreover, overexpression of DNA methyltransferases results in promoter hypermethylation, which can suppress the transcription of genes involved in DNA repair. Several DDR mechanisms have been recognized so far, with homologous recombination (HR) being the main pathway involved in the repair of double-strand breaks. An increasing number of defective HR genes are emerging in GC, resulting in the identification of important determinants of therapeutic response to DDR inhibitors. This review describes how both histone and DNA methylation affect DDR in the context of GC and discusses how alterations in DDR can help identify new molecular targets to devise more effective therapeutic strategies for GC, with a particular focus on HR-deficient tumors.

show abstract

Low expression of CDK12 in gastric cancer is correlated with advanced stage and poor outcome

Cited by 8 publications

References 32 publications

Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities

Contact Info

Product

Resources

About