Low frequency of protective variants at regulatory region of PRNP gene indicating the genetically high risk of BSE in Ethiopian Bos indicus and Bos taurus africanus

Teferedegn, Eden Yitna; Can, Hüseyin; Alak, Sedef Erkunt; Ün, Cemal

doi:10.1080/10495398.2022.2058007

Cited by 2 publications

(2 citation statements)

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“…This is consistent with previous reports in Bos indicus and Bos taurus x Bos indicus composite breeds (Brunelle et al 2008). The frequency of the del12 allele was also high in the studied Ethiopian breeds, contrary to what was reported by Brunelle et al (2008), placing them in a position of genetic vulnerability to the disease (Teferedegn et al 2022).…”

Section: Discussionsupporting

confidence: 91%

“…However, the del23 allele was the majority in South Anatolian Red and East Anatolian Red (del23=0.64,del23=0.6), being lower in Turkish Gray (del23=0.38). Teferedegn et al (2022) recently observed a high frequency of the del23 allele in four local Ethiopian breeds (Afar, Arsi, Fogera, and Ethiopian Borona). This is consistent with previous reports in Bos indicus and Bos taurus x Bos indicus composite breeds (Brunelle et al 2008).…”

Section: Discussionmentioning

confidence: 97%

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Comparative analysis of PRNP 12-bp and 23-bp indels in healthy Aberdeen Angus, Aberdeen Angus x Hereford, Holstein Friesian and Uruguayan Creole cattle

Artigas,

Vazquez,

Nicolini

et al. 2023

Pesq. Vet. Bras.

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Bovine spongiform encephalopathy (BSE) is a transmissible progressive neurodegenerative disease characterized by the accumulation of a pathological isoform (PrpSC) of the cellular prion protein (PrpC) in the brain of cattle. Two insertion/deletion polymorphisms in the PRNP gene (23bp in the promoter and 12bp in intron 1) have been associated with resistance or susceptibility to the disease. The aim of this study was to analyze the distribution of these polymorphisms in 214 healthy bovines belonging to four different breed groups (Aberdeen Angus, Aberdeen Angus x Hereford, Holstein Friesian and Uruguayan Creole cattle). DNA samples were amplified by end-point PCR. A high frequency of the alleles and haplotype associated with susceptibility to BSE (del12 and del23, and del12-del23, respectively) were found in the Aberdeen Angus, Aberdeen Angus x Hereford and Holstein Friesian animals. At the same time, the Uruguayan Creole cattle presented a higher frequency of the alleles and haplotype associated with resistance to BSE (ins12 and ins23, and ins12-ins23, respectively). These data could indicate a greater genetic resistance of the Uruguayan Creole cattle to BSE compared to other analyzed breeds, reinforcing its value as a zoogenetic resource.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%