Low-Grade B Cell Lymphoproliferative Disorder Masquerading as Chronic Rhinosinusitis

Abstract

Pediatric chronic rhinosinusitis (CRS) remains an elusive diagnostic medical condition, largely based on imperfect diagnostic criteria, lack of controlled studies of therapy, lack of measure for resolution, and lack of information of pediatric sinus microbiome dysbiosis. The true prevalence of pediatric CRS is unknown, and symptoms often over-lap with other diagnoses. We review the unmet needs in pediatric CRS, to highlight potential research opportunities to improve understanding and therapy of the disease process.

Allergic Rhinosinusitis and Airway Diseases

“…This Special Issue, "Allergic Rhinosinusitis and Airway Diseases", concludes with the ninth paper presenting an interesting clinical case, entitled "Low-Grade B Cell Lymphoproliferative Disorder Masquerading as Chronic Rhinosinusitis", reported by Chen et al [19]. In this case report, a 72-year-old man was referred by his general practitioner for symptoms mimicking chronic rhinosinusitis unresponsive to local corticosteroid treatment and antibiotics.…”

“…Progress in diagnosis, with the use of the advanced biomarkers and relevant imagery techniques associated with accurate treatment of chronic rhinosinusitis and lower airway diseases, should continue to be developed in the future. Coronal CT sinus image depicting disease affecting the ethmoid bullae and ostio-meatal complex [19].…”

“…Figure 2. Transverse CT chest image with arrows indicating mediastinal and hilar lymphadenopathy.Coronal CT sinus image depicting disease affecting the ethmoid bullae and ostio-meatal complex[19].…”