Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases

Ashrafganjoei, Tahereh; Behtash, Nadereh; Shariat, Mamak; Mosavi, Amir

doi:10.1186/1477-7819-4-50

Cited by 50 publications

(28 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19,20 Based on previous reports, tumors in 65-86% patients with ESS were confined to the uterine corpus at early-stage diagnoses. 10,21,22 This disease was also known to affect females in their 50s to 60s while our data showed that patients with stage I…”

Section: Discussionmentioning

confidence: 53%

Long‐term impact of lymphadenectomies in patients with low‐grade, early‐stage uterine endometrial stroma sarcoma

Zhang

Wang

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim The aim of our study was to investigate the lymph node metastasis (LNM) rate and effect of lymph node dissection (LND) in patients with stage I, low‐grade endometrial stromal sarcoma (LGESS). Methods Patients with stage I LGESS (n = 119) that underwent surgery from July 1969 to July 2017, following up over 48 years at the China National Cancer Center were retrospectively analyzed in this study. Results Surgical records and consulting data for patients with LGESS were analyzed to find that 47 patients received systematic pelvic LND. The number of patients with menopause in the LND(+) group were significantly lower than those in LND(−) group (2.1% vs 22.2%, P = 0.005), meanwhile, patients received bilateral salpingo‐oophorectomy procedure in LND(+) group were significantly higher than LND(−) (97.9% vs 58.3%, P < 0.001). Neither progression‐free survival nor overall survival was significantly improved in the LND(+) group even after propensity score matching although the progression‐free survival has a stronger trend in LND(+) population. Conclusion A systematic LND was not significantly associated with prognosis for patients with early‐stage LGESS. There is no sufficient indication for a systematic LND for patients with early‐stage LGESS. A systematic LND might be necessary if enlarged lymph nodes were detected by image graphology or observation during surgery.

show abstract

Section: Discussionmentioning

confidence: 53%

Long‐term impact of lymphadenectomies in patients with low‐grade, early‐stage uterine endometrial stroma sarcoma

Zhang

Wang

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…Patients with pulmonary metastases of low-grade ESS usually have no specific symptoms. A number of patients have pulmonary metastasis at the initial diagnosis of low-grade ESS and this may be accompanied by corresponding respiratory symptoms (3,6,7). In the present study, the most common pulmonary symptom was dyspnea, followed by chest pain, pneumothorax and coughing.…”

Section: Discussionmentioning

confidence: 99%

Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review

et al. 2019

View full text Add to dashboard Cite

Pulmonary metastases of endometrial stromal sarcoma (ESS) are uncommon and can be difficult to diagnose. The aims of the present study were to investigate the clinical and pathological features, and enhance the awareness of pulmonary metastases in patients with low-grade ESS. The study reports a case of low-grade ESS that resulted in cystic and nodular pulmonary metastases. Furthermore, the PubMed database was searched using ‘pulmonary metastases of low-grade endometrial stromal sarcoma’ as the key phrase. The literature on pulmonary metastases of low-grade ESS was reviewed and 35 cases were included in the present study. The clinical manifestations, imaging data, pathological features, treatment and prognosis of the 35 previously reported cases and the current case were retrospectively analyzed. The age range of the 36 patients diagnosed with low-grade ESS was 28–65 years. The time period from confirmation of ESS to lung metastases was 1.5–27 years. In 50% of the patients, the pulmonary metastases were asymptomatic. The most common pulmonary symptom was dyspnea, followed by chest pain, pneumothorax and coughing. The most common chest imaging presentation was multiple pulmonary nodules, followed by a solitary nodule or mass. Histology was used to identify that the pulmonary metastases had the pathological features of low-grade ESS. The immunohistochemical results demonstrated strong diffuse immunoreactivity for cluster of differentiation 10, estrogen receptor and progesterone receptor in almost all the specimens. The review of the literature revealed that pulmonary metastases from low-grade ESS are rare but not negligible. Furthermore, the detailed clinical information, imaging findings and immunohistochemical detection are important for making a diagnosis.

show abstract

“…It has been established that LG-ESS is generally more common in younger women with a mean age between 45 and 57 [ 6 ]. However, affected older women had worse overall survival and progression [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Primary low-grade endometrial stromal sarcoma arising in the vagina: report of an unusual case and literature review

Jamea

Rikabi

Akkour

2017

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Endometrial stromal sarcoma rarely occurs as an extrauterine neoplasm and it is even more unlikely to be found in the vagina. To the best of our knowledge, only six cases of primary vaginal endometrial stromal sarcoma without association with endometriosis have been published to this day. We describe a case of a 58-year-old female with a history of vaginal heaviness caused by a mass lesion. After a biopsy was taken, the histopathological findings and immunohistochemical stains were consistent with low-grade endometrial stromal sarcoma. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy with lymph node dissection followed by hormonal therapy. This line of management was heavily based on the treatment guidelines for endometrial stromal sarcoma.

show abstract

Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases

Abstract: Five-year survival rate was 93%. Survival probabilities were calculated by the product limit method of Kaplan and Meier that showed, patients with no myometrial invasion and low mitotic count < or = 5/HPF have longer disease-free survival, but P value was not significant.

Cited by 50 publications

References 18 publications

Long‐term impact of lymphadenectomies in patients with low‐grade, early‐stage uterine endometrial stroma sarcoma

Long‐term impact of lymphadenectomies in patients with low‐grade, early‐stage uterine endometrial stroma sarcoma

Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review

Primary low-grade endometrial stromal sarcoma arising in the vagina: report of an unusual case and literature review

Contact Info

Product

Resources

About