Low grade gastric B‐cell MALT lymphoma progressing into high grade lymphoma. Clonal identity of the two stages of the tumour, unusual bone involvement and leukaemic dissemination

Montalbán, Carlos; Manzanal, A.; Castrillo, J. M.; Escribano, Luís; Bellas, Carmen

doi:10.1111/j.1365-2559.1995.tb00299.x

“…The prognostic significance of older age and histological type in our study is comparable to the results of other studies [13,20,21]. The prognosis was significantly better for lymphoma than for adenocarcinoma, and prognosis was worse for undifferentiated carcinoma than for adenocarcinoma.…”

Section: Discussionsupporting

confidence: 81%

Trends in the management of gastric cancer over a 32-year period: a French population-based study

Herbreteau

¹

,

Jooste

²

,

Hamza

³

et al. 2014

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Background Gastric cancer is still generating interest because of its poor prognosis. The aim of this study was to investigate time trends in diagnostic assessment, patterns of care, and survival of gastric cancers. Methods We considered 5,010 gastric cancers diagnosed between 1976 and 2007 in a well-defined French population. Logistic regressions were used to identify factors associated with R0 resection and operative mortality. A multivariate relative survival analysis was performed. Results Diagnostic modalities have changed. Since 1988, endoscopy is performed when gastric cancer is suspected (95.5 %). However, there has been no strong variation in stage over time: the proportion of stage I cancers increased from 5.5 % to 13.4 % between the periods 1976-1979 and 2004-2007 (p \ 0.001) whereas that of advanced cases remained stable, 64.8 % and 65.0 %, respectively. R0 resections rose from 36.7 % (1976-1979) to 46.7 % between 1980 and 1999, and decreased to 32.7 % thereafter. Age, tumor location, and period were associated with R0 resection. Neoadjuvant and adjuvant chemotherapy were rarely used before 2000, then reached 15.0 % and 19.1 %, respectively, during the later period. Operative mortality after R0 resection decreased from 18.3 % during the 1976-1979 period to 4.3 % during the 2004-2007 period (p \ 0.001). Prognosis slightly improved during the three first periods, from 13.0 % to 22.6 %, then leveled off, not exceeding 26.0 % thereafter. Stage, age, histology, and time period significantly influenced survival. Conclusion Changes in diagnostic modalities were associated with minor changes in stage and prognosis for gastric cancer. Earlier diagnosis and new therapeutic strategies are the best way to improve the prognosis.

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“…Some studies are supportive of a lymphomagenesis of high-grade MALT lymphoma from low-grade MALT lymphoma, eg by showing clonal relationship between low-and high-grade lymphoma cells. 3,4,[43][44][45] It might be hypothesised that MALT lymphocytes undergo a sequence of genetic changes that ultimately lead to high-grade MALT lymphoma. In this case, one would expect to find aberrations of the low-grade tumour to be present in the high-grade tumour cells as well.…”

Section: Discussionmentioning

confidence: 99%

Gastric low-grade MALT lymphoma, high-grade MALT lymphoma and diffuse large B cell lymphoma show different frequencies of trisomy

Hoeve

¹

,

Gisbertz

²

,

Schouten

³

et al. 1999

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Gastric MALT lymphoma is a distinct entity related to Helicobacter pylori gastritis. Some studies suggest a role for trisomy 3 in the genesis of these lymphomas, but they mainly focused on low-grade MALT lymphoma. Gastric MALT lymphoma, however, comprises a spectrum from low-to high-grade cases. Furthermore, its exact relation to primary diffuse large B cell lymphoma (DLBCL) of the stomach is not clear. We applied in situ hybridisation (ISH) with centromeric probes on 43 samples of 39 patients with primary gastric lymphoma (13 samples with low-grade MALT lymphoma, 25 with high-grade MALT lymphoma and five with DLBCL) to detect numerical aberrations of 10 chromosomes. ISH was performed immunohistochemically on nuclei isolated from paraffin-embedded resection tissue and on whole paraffin sections using immunofluorescence. In six of 13 low-grade MALT lymphomas trisomy was detected (46%) and mostly involved chromosome 3 (33%). In high-grade MALT lymphomas, trisomies were found in 16 of 25 cases (64%), mainly involving chromosomes 12 and 18. Trisomy 3 was present in only 13% of these cases. Of five DLBCL, only one showed trisomy. Nine of the 16 aberrant high-grade MALT lymphomas (56%) showed trisomy of more than one chromosome per case vs two of six for low-grade cases. In lymphomas with separate low-and high-grade tumour components some trisomies were detected in both components, whereas others occurred only in the high-grade tumour cells. This supports the hypothesis that high-grade MALT lymphomas can develop from a low-grade type and that this progression is accompanied by the acquisition of more genetic aberrations. However, trisomy 3 probably does not play a major role in this progression.

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“…Although first described as a low-grade lymphoma, transformation into a large cell lymphoma is now well established. 3,4 In some studies, these lymphomas are designated as high-grade MALT lymphomas. Similarly, primary large cell lymphoma with features of MALT lymphoma such as lymphoepithelial lesions or an accompanying small cell component are often classified as high-grade MALT lymphoma.…”

Section: Introductionmentioning

confidence: 99%

True

1999

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Gastric MALT lymphoma is a distinct entity related to Helicobacter pylori gastritis. Some studies suggest a role for trisomy 3 in the genesis of these lymphomas, but they mainly focused on low-grade MALT lymphoma. Gastric MALT lymphoma, however, comprises a spectrum from low-to high-grade cases. Furthermore, its exact relation to primary diffuse large B cell lymphoma (DLBCL) of the stomach is not clear. We applied in situ hybridisation (ISH) with centromeric probes on 43 samples of 39 patients with primary gastric lymphoma (13 samples with low-grade MALT lymphoma, 25 with high-grade MALT lymphoma and five with DLBCL) to detect numerical aberrations of 10 chromosomes. ISH was performed immunohistochemically on nuclei isolated from paraffin-embedded resection tissue and on whole paraffin sections using immunofluorescence. In six of 13 low-grade MALT lymphomas trisomy was detected (46%) and mostly involved chromosome 3 (33%). In high-grade MALT lymphomas, trisomies were found in 16 of 25 cases (64%), mainly involving chromosomes 12 and 18. Trisomy 3 was present in only 13% of these cases. Of five DLBCL, only one showed trisomy. Nine of the 16 aberrant high-grade MALT lymphomas (56%) showed trisomy of more than one chromosome per case vs two of six for low-grade cases. In lymphomas with separate low-and high-grade tumour components some trisomies were detected in both components, whereas others occurred only in the high-grade tumour cells. This supports the hypothesis that high-grade MALT lymphomas can develop from a low-grade type and that this progression is accompanied by the acquisition of more genetic aberrations. However, trisomy 3 probably does not play a major role in this progression.

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Low grade gastric B‐cell MALT lymphoma progressing into high grade lymphoma. Clonal identity of the two stages of the tumour, unusual bone involvement and leukaemic dissemination

Cited by 67 publications

References 4 publications

Trends in the management of gastric cancer over a 32-year period: a French population-based study

Trends in the management of gastric cancer over a 32-year period: a French population-based study

Gastric low-grade MALT lymphoma, high-grade MALT lymphoma and diffuse large B cell lymphoma show different frequencies of trisomy

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