Low hepatic lipase activity is a risk factor for coronary artery disease

Dugi, Klaus A.; Brandauer, Karin; Schmidt, Nikolaus; Ramacher, Dirk; Kreuzer, Joerg

doi:10.1016/s0021-9150(00)80570-5

Cited by 2 publications

(1 citation statement)

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“…174 Despite the inverse correlation between HL activity and HDL-C, a low HL activity has been associated with the presence of atherosclerosis. 181 Knockout of HL led to the occurrence of an atherogenic lipoprotein phenotype but reduced atherosclerosis in apoE-deficient mice. 182 Transgenic overexpression of HL in either mice or rabbits decreased HDL-C levels but did not cause atherosclerosis.…”

Section: Hl and Elmentioning

confidence: 98%

High Density Lipoproteins and Arteriosclerosis

Eckardstein

Nofer

Assmann

2001

ATVB

604

128

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Abstract-High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs. Enhancement of cholesterol efflux and of reverse cholesterol transport (RCT) is considered an important target for antiatherosclerotic drug therapy. Levels and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters. In vitro experiments as well as genetic family and population studies and investigation of transgenic animal models have revealed that HDL cholesterol plasma levels do not necessarily reflect the efficacy and antiatherogenicity of RCT. Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for efflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis. (Arterioscler Thromb Vasc Biol. 2001;21:13-27.)

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Section: Hl and Elmentioning

confidence: 98%

High Density Lipoproteins and Arteriosclerosis

Eckardstein

Nofer

Assmann

2001

ATVB

604

128

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Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?

Eckardstein

Assmann

2000

Current Opinion in Lipidology

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Consistent with several potentially anti-atherogenic activities of high-density lipoproteins in vitro, low plasma levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease. In addition to genes, lifestyle factors (e.g. smoking, being overweight and physical inactivity) strongly affect plasma high-density lipoprotein cholesterol levels. Moreover, a low level of high-density lipoprotein cholesterol interacts with other risk factors. Raising of high-density lipoprotein cholesterol by either adjustments of lifestyle or drug intervention as well as elimination of additional risk factors are thus thought to affect coronary risk. Here, we summarize the outcomes of observational and interventional studies as well as genetic and experimental research which have recently much advanced our understanding of the function and regulation of high-density lipoprotein metabolism. We conclude from the data that changes in the kinetics and functionality of high-density lipoprotein rather than changes in plasma high-density lipoprotein cholesterol levels per se will affect the anti-atherogenicity of therapeutic interference with high-density lipoprotein metabolism.

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Low hepatic lipase activity is a risk factor for coronary artery disease

Cited by 2 publications

References 0 publications

High Density Lipoproteins and Arteriosclerosis

High Density Lipoproteins and Arteriosclerosis

Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?

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