Low insulin resistance after surgery predicts poor GH suppression one year after complete resection for acromegaly: a retrospective study

Pitfalls in early biochemical evaluation after transsphenoidal surgery in patients with acromegaly

“…In our previous study, we found out that insulin resistance immediately after surgery was predictive of and correlated with the GH naidr at the first postoperative year evaluation [26]. Although the relationship between insulin resistance and the GH nadir is unclear, we suggested that defective central somatostatin tone as a possible cause of impaired GH suppression [27].…”