Background: Lymphatic Filariasis (LF) is an infectious disease caused by filarialworms and transmitted by mosquitoes. Mass drug administration (MDA) for LF isused in endemic areas to stop transmission and prevent disability due to LF. Thisstudy aims to identify factors associated with overall compliance with the MDA in2018 in the catchment areas of Waihaong and Air Salobar Health Centers, Ambon.Method: This analysis used data derived from a survey conducted by the Facultyof Medicine Pattimura University, Ambon, in January 2019. We used informationfrom 745 subjects who received LF drugs in both study areas. Logistic regressionanalysis was employed to determine factors associated with community compliancewith taking filariasis drugs.Results: Our study found that only 67% of the community swallowed LF drugs(60,3% in Waihaong and 72,6% in Air Salobar). Higher compliance withswallowing the LF drugs was found in respondents living in the catchment area ofAir Salobar Health Center (OR=2,01, 95%CI:1,42-2,86, P-value<0,001);with ahigh level of knowledge (OR=1,91, 95%CI:1,34-2,74, P-value<0,001 and with ahigh sense of trust towards the drugs deliverers (OR=4,93, 95%CI:2,17-11,22, Pvalue<0,001). Furthermore, respondents who felt a high moral obligation to takethe drugs (OR=2,39, 95%CI:1,15-4,94, P-value=0,019); and received socialsupport to take the drugs (OR=5,12, 95%CI:3,18-8,23, P-value<0,001) were alsomore likely to comply with treatment. This study shows that health promotioninterventions to increase community awareness and knowledge are still required inAmbon City despite many rounds of mass drug administration. Various educationalmedia and efforts to increase knowledge and capabilities of the drug deliverers areessential to improve community compliance with taking LF drugs.