Efficient frame synchronization is essential for data recovery in communication systems. In this study, a single pilot sequence is used to achieve both frame synchronization and peak-to-average power ratio (PAPR) reduction. The two systems considered are direct-current biased optical orthogonal frequency division multiplexing (DCO-OFDM) and asymmetrically clipped O-OFDM (ACO-OFDM). The pilot symbol is allocated to odd indexed subcarriers only. Thus, the synchronization algorithm leverages the mirror symmetric property of the pilot symbol within a frame to detect the start of the pilot signal at the receiver. This scheme has low complexity and gives precise frame synchronization at signal-to-noise ratios as low as 4 dB in an indoor visible light communication (VLC) channel.