Low-level exposure to pulsed 900 MHz microwave radiation does not cause deficits in the performance of a spatial learning task in mice

Sienkiewicz, Zenon; Blackwell, R. P.; Haylock, Richard; Saunders, Richard D. E.; Cobb, Brenda L.

doi:10.1002/(sici)1521-186x(200004)21:3<151::aid-bem1>3.0.co;2-q

Cited by 88 publications

(49 citation statements)

References 40 publications

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“…There was no difference between rats exposed for 45 min to 3.5 W/kg and sham exposed or cage control rats in performance of these tasks. A similar study using mice [Sienkiewicz et al, 2000] studied the effect of exposure to low intensity 900 MHz RFR pulsed at 217 Hz with a spatial learning and working memory task. Mice were exposed under far field conditions in a GTEM cell for 45 min each day for 10 days at an average whole body specific energy absorption rate (SAR) of 0.05 W/kg.…”

Section: Microwave Effects On Cognitive Behavior Effects On Cognitivementioning

confidence: 99%

Behavioral and cognitive effects of microwave exposure

D'Andrea

Adair

Lorge³

2003

Bioelectromagnetics

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This paper presents an overview of the recent behavioral literature concerning microwave exposure and discusses behavioral effects that have supported past exposure standards. Other effects, which are based on lower levels of exposure, are discussed as well, relative to setting exposure standards. The paper begins with a brief discussion of the ways in which behavioral end points are investigated in the laboratory, together with some of the methodological considerations pertinent to such studies when radio frequency (RF) exposure is involved. It has been pointed out by several sources that exposure to RF radiation can lead to changes in the behavior of humans and laboratory animals that can range from the perceptions of warmth and sound to lethal body temperatures. Behavior of laboratory animals can be perturbed and, under certain other conditions, animals will escape and subsequently avoid RF fields; but they will also work to obtain a burst of RF energy when they are cold. Reports of change of cognitive function (memory and learning) in humans and laboratory animals are in the scientific literature. Mostly, these are thermally mediated effects, but other low level effects are not so easily explained by thermal mechanisms. The phenomenon of behavioral disruption by microwave exposure, an operationally defined rate decrease (or rate increase), has served as the basis for human exposure guidelines since the early 1980s and still appears to be a very sensitive RF bioeffect. Nearly all evidence relates this phenomenon to the generation of heat in the tissues and reinforces the conclusion that behavioral changes observed in RF exposed animals are thermally mediated. Such behavioral alteration has been demonstrated in a variety of animal species and under several different conditions of RF exposure. Thermally based effects can clearly be hazardous to the organism and continue to be the best predictor of hazard for homosapiens. Nevertheless, similar research with man has not been conducted. Although some studies on human perception of RF exist, these should be expandedto include a variety of RF parameters.

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Section: Microwave Effects On Cognitive Behavior Effects On Cognitivementioning

confidence: 99%

Behavioral and cognitive effects of microwave exposure

D'Andrea

Adair

Lorge³

2003

Bioelectromagnetics

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“…In contrast, no effect of RF‐EMF exposure on spatial learning and working memory tasks was found [Sienkiewicz et al, 2000; Dubreuil et al, 2003; Maaroufi et al, 2014]. Moreover, other studies have reported a beneficial effect of RF‐EMF on cognitive function [Dragicevic et al, 2011; Arendash et al, 2012; Banaceur et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice

Son

Jeong

Kwon³

et al. 2016

Bioelectromagnetics

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The increased use of mobile phones has generated public concern about the impact of radiofrequency electromagnetic fields (RF‐EMF) on health. In the present study, we investigated whether RF‐EMFs induce molecular changes in amyloid precursor protein (APP) processing and amyloid beta (Aβ)‐related memory impairment in the 5xFAD mouse, which is a widely used amyloid animal model. The 5xFAD mice at the age of 1.5 months were assigned to two groups (RF‐EMF‐ and sham‐exposed groups, eight mice per group). The RF‐EMF group was placed in a reverberation chamber and exposed to 1950 MHz electromagnetic fields for 3 months (SAR 5 W/kg, 2 h/day, 5 days/week). The Y‐maze, Morris water maze, and novel object recognition memory test were used to evaluate spatial and non‐spatial memory following 3‐month RF‐EMF exposure. Furthermore, Aβ deposition and APP and carboxyl‐terminal fragment β (CTFβ) levels were evaluated in the hippocampus and cortex of 5xFAD mice, and plasma levels of Aβ peptides were also investigated. In behavioral tests, mice that were exposed to RF‐EMF for 3 months did not exhibit differences in spatial and non‐spatial memory compared to the sham‐exposed group, and no apparent change was evident in locomotor activity. Consistent with behavioral data, RF‐EMF did not alter APP and CTFβ levels or Aβ deposition in the brains of the 5xFAD mice. These findings indicate that 3‐month RF‐EMF exposure did not affect Aβ‐related memory impairment or Aβ accumulation in the 5xFAD Alzheimer's disease model. Bioelectromagnetics. 37:391–399, 2016. © 2016 The Authors Bioelectromagnetics published by Wiley Periodicals, Inc. on behalf of Bioelectromagnetics Society.

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“…Cosquer also studied the effect of exposure to a 2 450 MHz electromagnetic field on the behavior of the rats after 45 minutes of irradiation in an elevated maze and found that electromagnetic radiation had no effect on the rats' behavior (2). Furthermore, irradiation with waves at a frequency band of 900 MHz in radial and water mazes had no effects on the rats' spatial memory function (3,4,19,20). In one study, Dubreuil et al (3) showed that exposure to GSM-900 electromagnetic fields for 45 minutes before each training (10 days) had no effects on spatial learning in rats.…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted by Jadidi, 45 minutes of exposure to mobile phone radiation at 950 MHz had no effects on learning and the memory acquisition phase in rats (19). Sienkiewicz studied the effect of an electromagnetic field at 900 MHz on spatial learning in rats using an eight-armed radial maze and found that placing the rats in this field for 45 minutes each day for 10 consecutive days had no effects on their memories (20). However, at these frequency bands, cell phone waves affect human memory (21,22) and some of the studies have used water and radial mazes at a frequency of 2 450 MHz (7,8,23).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Acute Mobile Phone Radiation on the Anxiety Level of Male Rats

Esmaili

Masoumi

Jadidi

et al. 2017

Middle East J Rehabil Health Stud

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Objectives: Despite two decades of using mobile phone, the biological effects of electromagnetic radiation remain controversial. The study was conducted to determine the effect of mobile phone waves on anxiety-like behaviors in male rats. Methods: A total number of 80 male naive rats were, randomly, divided into eight groups (Control, 900, 1 800, and 2 100 MHz exposure). The acute and chronic effects of mobile phone radiation on the anxiety profile was compared considering a 45-min session and seven sessions of radiation (45 min/day) using the elevated plus-maze (EPM) in rats. The number of rats entering the open and closed arms and their duration of stay in each of the arms were assessed. To estimate the oxidative stress, Superoxide Dismutase level in the blood serum was evaluated. Results:The results obtained in the EPM showed no significant differences among the groups after acute exposure to mobile phone radiation (P > 0.05). No significant differences were observed among the groups in terms of their serum superoxide dismutase level (P > 0.05). Conclusions: Short time mobile phone radiation had no effect on anxiety-like behaviors and serum enzyme activity; this may be due to low tissue irritation during acute exposure to mobile phone waves.

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Low-level exposure to pulsed 900 MHz microwave radiation does not cause deficits in the performance of a spatial learning task in mice

Cited by 88 publications

References 40 publications

Behavioral and cognitive effects of microwave exposure

Behavioral and cognitive effects of microwave exposure

1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice

The Effects of Acute Mobile Phone Radiation on the Anxiety Level of Male Rats

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