Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers

Carvalho, Ana Flávia Machado de; Feitosa, Maura Cristina Porto; Coelho, Nayana Pinheiro Machado de Freitas; Rêbelo, Veruska Cronemberger Nogueira; Castro, Juçara Gonçalves de; Sousa, Patrícia Regina Gomes de; Feitosa, Valrian Campos; Arisawa, Emília Ângela Lo Schiavo

doi:10.1590/s0080-623420160000500013

Cited by 62 publications

(90 citation statements)

References 12 publications

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“…Three studies assessed the effect of calendula extract ointments on burns . Three studies assessed the effect on chronic wound healing, of which two studies included patients with leg ulcers due to venous insufficiency and one included patients with diabetic ulcers . One study assessed the effect of calendula extract ointment on acute wound healing…”

Section: Resultsmentioning

confidence: 99%

“…de Carvalho et al conducted a four‐arm randomized control trial on diabetes patients with leg ulcers for ulcer size reduction. Subjects were assigned to treatment with calendula extract oil ( n = 8), low‐level laser therapy ( n = 8), or a combination of both ( n = 8), compared to standard care control group ( n = 8) receiving daily cleaning and dressing (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…These two studies differed in their control groups and duration, and it is important to note that both studies were neither randomized nor blinded and had small sample sizes, which limits the strength of the evidence for the benefits of calendula. In the study by de Carvalho et al which assessed the effect of calendula extract on leg ulcers in patients with diabetes, there was no evidence for improved healing compared to control. This could be due to small vessel impairment common to diabetic patients, which prevents the diffusion of nutrients needed for increased fibroblasts metabolism and extracellular matrix production.…”

Section: Discussionmentioning

confidence: 96%

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A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

112

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Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of Calendula officinalis flower extract as monotherapy compared to control for wound healing in vivo. Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus (up to April 2018) with 14 studies meeting the inclusion criteria, comprising 7 animal experiments and 7 clinical trials. Findings from the review on acute wound healing showed faster resolution of the inflammation phase with increased production of granulation tissue in the test groups treated with extract. These findings were consistent in five animal studies and one randomized clinical trial. Chronic wound healing studies were varied. Two clinical control studies on venous ulcers demonstrated decreased ulcer surface area compared to controls. Another randomized clinical trial demonstrated no improvement for the calendula group in diabetic leg ulcer healing. Burn healing similarly showed mixed results. Two animal studies demonstrated a prophylactic effect for the administration of calendula extract prior to burn injury. A randomized clinical trial of patients suffering from partial to full thickness burns demonstrated no benefit for topical application of calendula extract compared to controls. Two randomized clinical trials assessed the potential for extract to prevent acute post radiation dermatitis, with one study showing improvements compared to trolamine, while the other found no improvement compared to aqua gel cream. Animal studies provide moderate evidence for improved recovery from the inflammation phase and increased production of granulation tissue in calendula extract treatment groups. This review identified some evidence for the beneficial effects of C. officinalis extract for wound healing, consistent with its role in traditional medicine. There is a need for larger, well‐designed randomized control trials to assess the effect of calendula on wound healing including complications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

112

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“…In the existing literature, few studies are available in this area. 14,[19][20][21][22][23][24] The current study was aimed to assess the adequacy of a treatment modality with LLLT for diabetic foot ulcers.…”

Section: Discussionmentioning

confidence: 99%

“…Even though many studies have listed in literature on the efficacy of low level laser therapy to treat DFUs, but in Indian scenario there are minimum number of studies. 14,[19][20][21][22][23][24] There is a need in India to accelerate the research on the viability of low level laser therapy to avoid the backlogging in its implementation. The aim of this study was to study the role of LLLT on diabetic ulcers, i.e.…”

mentioning

confidence: 99%

Effect of low level laser therapy on diabetic foot ulcers: a randomized control trial

2018

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Background: Nearly 15% of diabetic patients will suffer from DFU in their life span. Conventional treatment is not effective against the non-healing DFUs so in recent days so many adjuvant therapies which have been tried to stimulate healing process are in use. LLLT, is a non-invasive, pain-free method is considered as a possible treatment option for the diabetic foot syndrome. Aim of this study is to study the role of low level laser therapy on diabetic ulcers, i.e. Reduction in size of the ulcer, faster wound healing, control of infection, cost effectiveness and if secondary procedures like split skin grafting can be avoided.Methods: A total of 100 patients with Diabetic foot ulcer fitting the inclusion criteria was included in the study and they were randomly categorized into control and study group. Patients in the study group received treatment with LLLT. Ulcer bed with edge was irradiated locally with red light (660nm), about 4-8J/cm2 for 20 minutes was delivered for 15 days on daily basis. Conventional dressing was preferred for covering after irradiation and controls were treated with conventional therapy alone which includes dressings with betadine or wet with saline, Course of antibiotic treatment and sloughs removed whenever needed. The size, grade and culture status of the ulcer was assessed on Day 1 and day 15. Duration of stay in hospital was noted to assess cost effectiveness.Results: In LLLT group, after completing 15 days treatment complete wound healing was achieved in 66.6% of grade-1 ulcers and 4.4% of grade-2 ulcers and 96.6% of grade-2 ulcers improved to grade-1. In contrary only 3.4% of grade-2 ulcers improved to Grade 1 and a majority of ulcers remained as such. Reduction in Mean area of ulcer at day-15 was statistically significant in LLLT group (13.74±11.88 to 3.97±5.41cm2 and P<0.001) whereas reduction of mean ulcer area among controls was statistically not significant (19.09±15.03cm2 to 18.80±17.70cm2 and P=0.859). Mean total cost of the treatment was less compared to conventional treatment group. (2264.3±140 Vs 3588.4±68 Rs).Conclusions: Laser therapy is painless, cost effective procedure which induces faster granulation, wound contraction and reepithelialisation, thus accelerates complete wound healing hence avoiding secondary procedures like split skin grafting. Control of infection was also better compared to control group.

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Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

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In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound‐healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound‐healing purposes, and scientific data were found for some of those plants. However, the wound‐healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.

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Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers

Cited by 62 publications

References 12 publications

A systematic review of Calendula officinalis extract for wound healing

A systematic review of Calendula officinalis extract for wound healing

Effect of low level laser therapy on diabetic foot ulcers: a randomized control trial

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

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