Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement

Varella, Alissa Maria; Revankar, Ameet V; Patil, Anand

doi:10.1016/j.ajodo.2018.01.012

Cited by 51 publications

(61 citation statements)

References 28 publications

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“…Cruz et al, 13 (first accomplished human subject studies) conducted a 2-month study on 11 patients to evaluate the rate of tooth motion and indicated significantly higher acceleration of canine retraction in the laser-treated group. Eight studies 12,19,[22][23][24][25][26][27] showed similar results to those obtained by Cruz et al, but 2 studies 20, 21 like Limpanichkul et al 43 studied maxillary canine retraction in 12 young adult patients and found no significant differences in the rate of tooth movement over a 3-month period because of high-level energy density, and they stated that there was no significant difference between the LLLT side and the placebo or controlled side.…”

Section: Discussionmentioning

confidence: 56%

“…Varella et al 23 : In this split-mouth study, at all of the time points, the quantities of canine retraction for the laser group were higher than those for the control canines (P < 0.001).…”

Section: Search Resultsmentioning

confidence: 61%

“…Üretürk et al 24 concluded that all subjects had excellent gingival and periodontal status at all time points of experiment with no significant difference in the plaque index, the gingival index, and the bleeding scores. Varella et al 23 showed plaque accumulation was negligible and periodontal decimation was not found in any subject pending the investigation.…”

Section: Genc Et Al 26mentioning

confidence: 94%

“…Varella et al 23 LLLT-facilitated orthodontics is approximately 2 times faster than conventional orthodontics.…”

Section: Qamruddin Et Al 22mentioning

confidence: 99%

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The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

2020

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In clinical practice, low-level laser therapy (LLLT) is widely used. The main aim of this review is to assess the effectiveness of LLLT in accelerating tooth movement in human subjects. The PRISMA checklist was utilized as a guideline to carry out this systematic review. The electronic databases were searched from Google Scholar (2014-2018) and PubMed, and comprehensive research on this topic was also manually conducted. Therefore, 77 articles randomized clinical trials (RCTs) or controlled clinical trials (CCTs) were selected. After screening studies, consequently, eleven trials met the inclusion criteria. Eight out of 11 studies showed LLLT has a significant impact on the acceleration of orthodontic tooth movement, and there was no statistically significant difference in the rate of tooth movement between the laser group and the control group in the two remaining studies. Furthermore, five out of 11 articles showed that LLLT has no adverse effects. Although we have some degree of understanding from a cellular point of view to LLLT effects, we still do not know whether these cellular level changes have any effect on the clinical acceleration of orthodontic tooth movement. The results are inconclusive and cannot be generalized to the public community; therefore, well-structured studies are required.

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Section: Discussionmentioning

confidence: 56%

Section: Search Resultsmentioning

confidence: 61%

Section: Genc Et Al 26mentioning

confidence: 94%

“…Varella et al 23 LLLT-facilitated orthodontics is approximately 2 times faster than conventional orthodontics.…”

Section: Qamruddin Et Al 22mentioning

confidence: 99%

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The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

2020

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“…Our study revealed an increased level of cytokines whenever orthodontic force was applied (G2 and G3), regardless of laser irradiation, especially after 30 days of sample collection, a significant increase in IL1-β, IL-6 and IL-8 was observed in the laser-irradiated group (G3), compared with groups G1 and G2 (P < 0.05). Varella et al, [53] also presented a study where IL-1β increased especially due to PBM. Yanaguizawa et al [31] stated that PBM promoted a significant modulation of IL-8 levels when compared to a non-irradiated group.…”

Section: Discussionmentioning

confidence: 92%

Photobiomodulation increases intrusion tooth movement and modulates IL‐6, IL‐8 and IL‐1β expression during orthodontically bone remodeling

Fernandes

Suzuki

et al. 2019

Journal of Biophotonics

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This study investigated the effects of photobiomodulation (PBM) on upper molar intrusion movement, regarding acceleration of orthodontic movement and its molecular effects. The sample consisted of 30 patients with indication of tooth intrusion for oral rehabilitation. Teeth were divided into three different groups: G1 (n = 10) pre‐molars without force or laser application (control); G2 (n = 10) upper molar intrusion; and G3 (n = 10) upper molar intrusion and PBM. On PBM treated molars, the teeth were irradiated with a low‐power diode laser (808 nm, 100 mW), receiving 1 J per point, density of 25 J/cm2, with application of 10 s per point, 10 points (5 per vestibular and 5 per palatal region). Orthodontic force of intrusion applied every 30 days and PBM was performed immediately, 3 and 7 days after force application for 3 months. Gingival crevicular fluid was collected at the same time periods as the laser applications and interleukins (IL) 1‐β, ‐6 and ‐8 were evaluated by enzyme‐linked immunosorbent assay. Clinical measures were performed monthly to verify the amount of intrusion. The levels of IL‐6, IL‐8 and IL‐1β increased under orthodontic force (G2 and G3) when compared to control group (G1), however, the cytokines levels were significantly higher after PBM (G3). The mean intrusion velocity was 0.26 mm/month in the irradiated group (G3), average duration of 8 months vs 0.17 mm/month for the non‐irradiated group (G2), average duration of 12 months. This study suggests that PBM accelerates tooth movement during molar intrusion, due to modulation of IL‐6, IL‐8 and IL‐1β during bone remodeling.

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Biological Orthodontics

Krishnan¹,

Davidovitch²,

Kuijpers-Jagtman³

2021

Biological Mechanisms of Tooth Movement

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Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement

Cited by 51 publications

References 28 publications

The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

Photobiomodulation increases intrusion tooth movement and modulates IL‐6, IL‐8 and IL‐1β expression during orthodontically bone remodeling

Biological Orthodontics

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