Low Level Laser therapy (LLL) modulates pulmonary immune response and expression of P2X7 purinergic receptor in experimental model of Chronic Obstructive Pulmonary Disorder (COPD)

Alves, Cintia Estefano; Moraes, Gabriel; Brito, Auriléia Aparecida de; Rigonato‐Oliveira, Nicole Cristine; Vitoretti, Luana Beatriz; Soares, Stephany Souza; Matos, Yves Silva Teles; Brandão-Rangel, Maysa Alves Rodrigues; Aimbire, Flávio; Vieira, Rodolfo de Paula; Ligeiro-Oliveira, Ana Paula; Dias, Alana dos Santos

doi:10.1183/1393003.congress-2017.pa4457

Cited by 2 publications

(4 citation statements)

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“…The COVID-19 profile associated with admission to ICU is related to IL-1β and IFNγ, which are correlated with the re-sponse of Th-1 cells, while IL-4 and IL-10 are correlated with the response of Th-2 cells, and IL-6 and TNF-α are related to the innate immune response. Several studies have revealed the effectiveness of PBM in the pulmonary immune response in COPD [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Important molecular changes occur in the injured lung tissue: increase of proinflammatory cytokines (IL-1β, TNF-α, IL-6, IL-17) and chemokine (CXXL1/KC), decrease in peri bronchial density, collagen production, widening of the alveoli, increase in expression of purinergic receptor P2X7 and cell death [30]. PMB reduces the number of cells din broncho-alveolar lavage fluid, so it can be a tool for regulating IL-4 and IL-10 correlated with the Th-2 response from Covid-19.…”

Section: Discussionmentioning

confidence: 99%

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Post covid lung recovery through physiotherapy: A case report

Alina¹,

Alexandru²

2022

J Clin Images Med Case Rep

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SARS COV 2 infection causes lung lesions characterized by the appearance of ground glass opacities, and a significant percentage of patients present persistent symptoms and changes in CT scan represented by fibrotic lesions, traction bronchiectasis, persistence of ground glass images. Laser therapy has anti-inflammatory effects, stabilizes the vascular endothelium, has antifibrotic effects, being a useful therapy both in the acute phase of SARS COV2 pneumonia, as well as in the post-acute and chronic phase, rapidly reducing the symptomatology and being able to prevent the appearance of sequelae.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Post covid lung recovery through physiotherapy: A case report

Alina¹,

Alexandru²

2022

J Clin Images Med Case Rep

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“…As our findings in this critical review showed that COVID-19 dysregulates the immune response which is a feature of severe disease, the immune profile of SARS-CoV-2 associated with intensive care unit (ICU) admission is related to IL-1β and IFN gamma, which correlate with Th1 response, whereas IL-4 and IL-10 correlate with Th-2 response and IL-6 and TNF-α correlate with innate response. Several studies showed the effectiveness of utilising PBMT in modulating the pulmonary immune responses in COPD [14,21,92,93].…”

Section: Pbm Effects On Modulating the Immune Responsementioning

confidence: 99%

“…A study by Alves et al (2017) showed radical molecular changes in lung tissue injury: an increase in the anti-inflammatory cytokine IL-10; an augmentation in the production of proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-17) and chemokine (CXCL1/KC); and a decrease in the peri-bronchial density, collagen production, alveolar enlargement, P2X7 purinergic receptor expression and cell death 7AAD [ 92 ]. This study demonstrated that PBMT reduced the number of cells (Th2/Th17) in bronchoalveolar lavage (BAL).…”

Section: The Rational In Utilising Phototherapy In Covid-19 Managementioning

confidence: 99%

Phototherapy as a Rational Antioxidant Treatment Modality in COVID-19 Management; New Concept and Strategic Approach: Critical Review

et al. 2020

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The COVID-19 pandemic has taken the entire globe by storm. The pathogenesis of this virus has shown a cytokine storm release, which contributes to critical or severe multi-organ failure. Currently the ultimate treatment is palliative; however, many modalities have been introduced with effective or minimal outcomes. Meanwhile, enormous efforts are ongoing to produce safe vaccines and therapies. Phototherapy has a wide range of clinical applications against various maladies. This necessitates the exploration of the role of phototherapy, if any, for COVID-19. This critical review was conducted to understand COVID-19 disease and highlights the prevailing facts that link phototherapy utilisation as a potential treatment modality for SARS-CoV-2 viral infection. The results demonstrated phototherapy’s efficacy in regulating cytokines and inflammatory mediators, increasing angiogenesis and enhancing healing in chronic pulmonary inflammatory diseases. In conclusion, this review answered the following research question. Which molecular and cellular mechanisms of action of phototherapy have demonstrated great potential in enhancing the immune response and reducing host–viral interaction in COVID-19 patients? Therefore, phototherapy is a promising treatment modality, which needs to be validated further for COVID-19 by robust and rigorous randomised, double blind, placebo-controlled, clinical trials to evaluate its impartial outcomes and safety.

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Low Level Laser therapy (LLL) modulates pulmonary immune response and expression of P2X7 purinergic receptor in experimental model of Chronic Obstructive Pulmonary Disorder (COPD)

Cited by 2 publications

References 0 publications

Post covid lung recovery through physiotherapy: A case report

Post covid lung recovery through physiotherapy: A case report

Phototherapy as a Rational Antioxidant Treatment Modality in COVID-19 Management; New Concept and Strategic Approach: Critical Review

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