Low-Level Laser Therapy (LLLT) and AGA

Anastassakis, Konstantinos

doi:10.1007/978-3-031-10613-2_38

Cited by 2 publications

(1 citation statement)

References 111 publications

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“…Much effort has been made to reverse hair aging by boosting stem cell activity. Stem cell transplantation, hair follicle organoids, and stem cell-derived exosomes have gained attention as potential therapies to rejuvenate the HFs ( Anastassakis and Anastassakis, 2023 ).…”

Section: Treatmentmentioning

confidence: 99%

Signaling pathways in hair aging

Liang,

Fang,

et al. 2023

Front. Cell Dev. Biol.

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Hair follicle (HF) homeostasis is regulated by various signaling pathways. Disruption of such homeostasis leads to HF disorders, such as alopecia, pigment loss, and hair aging, which is causing severe health problems and aesthetic concerns. Among these disorders, hair aging is characterized by hair graying, hair loss, hair follicle miniaturization (HFM), and structural changes to the hair shaft. Hair aging occurs under physiological conditions, while premature hair aging is often associated with certain pathological conditions. Numerous investigations have been made to determine the mechanisms and explore treatments to prevent hair aging. The most well-known hypotheses about hair aging include oxidative stress, hormonal disorders, inflammation, as well as DNA damage and repair defects. Ultimately, these factors pose threats to HF cells, especially stem cells such as hair follicle stem cells, melanocyte stem cells, and mesenchymal stem cells, which hamper hair regeneration and pigmentation. Here, we summarize previous studies investigating the above mechanisms and the existing therapeutic methods for hair aging. We also provide insights into hair aging research and discuss the limitations and outlook.

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Section: Treatmentmentioning

confidence: 99%

Signaling pathways in hair aging

Liang,

Fang,

et al. 2023

Front. Cell Dev. Biol.

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The effects of fulvic acids and low-level laser therapy on orthodontic retention in rats

Zhao,

Liu,

Zhang

et al. 2024

BMC Oral Health

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Background Shortening retention time and minimizing relapse rates are ongoing challenges in orthodontics. This study investigated the effects of natural fulvic acids (FAs) and low-level laser therapy (LLLT) on orthodontic retention in rats. Methods Seventy-two male Sprague-Dawley rats underwent mesial movement of the left maxillary first molar using a 50 g force via a nickel-titanium tension spring. After three weeks of movement, the rats entered the retention phase with retainer wires and were divided into four groups: Control (no intervention), FAs (80 mg/kg orally daily), LLLT (808 nm laser twice weekly), and FAs + LLLT (both treatments). Retainers were removed on days 7, 14, and 21 for a 3-day relapse assessment. Maxillary impressions were analyzed for relapse rates using 3Shape software, alongside histological and immunohistochemical evaluations of bone morphogenetic protein-2 (BMP-2) expression in periodontal tissues, with differences among groups analyzed using an ordinary two-way analysis of variance (ANOVA). Results The relapse rate decreased over time, particularly at 10, 17, and 24 days ( p < 0.001). The FAs group did not significantly affect relapse rates compared to the control group ( p = 0.084). In contrast, both the LLLT and FAs + LLLT groups significantly reduced relapse rate ( p < 0.001), with no significant difference between these groups ( p = 0.555). Histological examination revealed active osteoclasts on day 10, decreasing by days 17 and 24. The LLLT and FAs + LLLT groups showed less local cementum resorption and better periodontal fiber arrangement. All treatment groups significantly increased BMP-2 expression ( P < 0.05) compared to controls. with LLLT and FAs + LLLT differing significantly from FAs ( P < 0.001), though no difference was observed between LLLT and FAs + LLLT ( P = 0.578). Conclusions FAs did not significantly reduce relapse rate with retainers, while LLLT effectively reduced relapse rates, showing no additional benefit from combining FAs with LLLT. Both FAs and LLLT increased BMP-2 expression in PDL fibroblasts but with no synergistic effect.

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Low-Level Laser Therapy (LLLT) and AGA

Cited by 2 publications

References 111 publications

Signaling pathways in hair aging

Signaling pathways in hair aging

The effects of fulvic acids and low-level laser therapy on orthodontic retention in rats

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